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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7UMB

NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0000187biological_processobsolete activation of MAPK activity
C0003056biological_processregulation of vascular associated smooth muscle contraction
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005078molecular_functionMAP-kinase scaffold activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006468biological_processprotein phosphorylation
C0006935biological_processchemotaxis
C0006979biological_processresponse to oxidative stress
C0007165biological_processsignal transduction
C0007507biological_processheart development
C0008285biological_processnegative regulation of cell population proliferation
C0010508biological_processpositive regulation of autophagy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0014044biological_processSchwann cell development
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0019901molecular_functionprotein kinase binding
C0021697biological_processcerebellar cortex formation
C0021953biological_processcentral nervous system neuron differentiation
C0030182biological_processneuron differentiation
C0030216biological_processkeratinocyte differentiation
C0030295molecular_functionprotein kinase activator activity
C0030335biological_processpositive regulation of cell migration
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030878biological_processthyroid gland development
C0031267molecular_functionsmall GTPase binding
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0032402biological_processmelanosome transport
C0032839cellular_componentdendrite cytoplasm
C0032872biological_processregulation of stress-activated MAPK cascade
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0034111biological_processnegative regulation of homotypic cell-cell adhesion
C0035987biological_processendodermal cell differentiation
C0036064cellular_componentciliary basal body
C0038133biological_processERBB2-ERBB3 signaling pathway
C0042552biological_processmyelination
C0043204cellular_componentperikaryon
C0043410biological_processpositive regulation of MAPK cascade
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0044342biological_processtype B pancreatic cell proliferation
C0044877molecular_functionprotein-containing complex binding
C0045893biological_processpositive regulation of DNA-templated transcription
C0045933biological_processpositive regulation of muscle contraction
C0046579biological_processpositive regulation of Ras protein signal transduction
C0047496biological_processvesicle transport along microtubule
C0048009biological_processinsulin-like growth factor receptor signaling pathway
C0048313biological_processGolgi inheritance
C0048471cellular_componentperinuclear region of cytoplasm
C0048538biological_processthymus development
C0048678biological_processresponse to axon injury
C0048679biological_processregulation of axon regeneration
C0048812biological_processneuron projection morphogenesis
C0048870biological_processcell motility
C0050772biological_processpositive regulation of axonogenesis
C0051384biological_processresponse to glucocorticoid
C0060020biological_processBergmann glial cell differentiation
C0060324biological_processface development
C0060425biological_processlung morphogenesis
C0060440biological_processtrachea formation
C0060502biological_processepithelial cell proliferation involved in lung morphogenesis
C0060674biological_processplacenta blood vessel development
C0060711biological_processlabyrinthine layer development
C0070328biological_processtriglyceride homeostasis
C0070371biological_processERK1 and ERK2 cascade
C0070372biological_processregulation of ERK1 and ERK2 cascade
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090170biological_processregulation of Golgi inheritance
C0090398biological_processcellular senescence
C0097110molecular_functionscaffold protein binding
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098978cellular_componentglutamatergic synapse
C0106310molecular_functionprotein serine kinase activity
C1903226biological_processpositive regulation of endodermal cell differentiation
C1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
C2000641biological_processregulation of early endosome to late endosome transport
C2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGNGGVVFkVshkpsglv..........MARK
ChainResidueDetails
CLEU74-LYS97
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKpsNILV
ChainResidueDetails
CILE186-VAL198
BILE782-TYR794
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"21441910","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21441910","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21441910","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15543157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17880056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18951019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19019675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310613","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"10409742","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-10-08

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