7OPB
| IL7R in complex with an antagonist | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ... | 著者 | Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N. | 登録日 | 2021-05-31 | 公開日 | 2022-05-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | 主引用文献 | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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6CMR
| Closed structure of active SHP2 mutant E76D bound to SHP099 inhibitor | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6CMP
| Closed structure of inactive SHP2 mutant C459E | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6CMQ
| Structure of human SHP2 without N-SH2 domain | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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6CMS
| Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Padua, R.A.P, Sun, Y, Marko, I, Pitsawong, W, Kern, D. | 登録日 | 2018-03-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9, 2018
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7S5B
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7Z3R
| Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor | 著者 | Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A. | 登録日 | 2022-03-02 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.951 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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7Z3P
| Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ... | 著者 | Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K. | 登録日 | 2022-03-02 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.943 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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7Z3Q
| Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution. | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N. | 登録日 | 2022-03-02 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.617 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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7RDH
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7N1J
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7N1K
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7N3T
| TrkA ECD complex with designed miniprotein ligand | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jude, K.M, Cao, L, Garcia, K.C. | 登録日 | 2021-06-01 | 公開日 | 2022-04-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
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7OX6
| Solution structure of human interleukin-9 | 分子名称: | Interleukin-9 | 著者 | Savvides, S.N, Tripsianes, K, De Vos, T, Papageorgiou, A, Evangelidis, T. | 登録日 | 2021-06-22 | 公開日 | 2022-12-28 | 最終更新日 | 2023-01-11 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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7OX5
| hIL-9:hIL-9Ra complex | 分子名称: | Interleukin-9, Interleukin-9 receptor, SULFATE ION | 著者 | De Vos, T, Savvides, S.N. | 登録日 | 2021-06-22 | 公開日 | 2022-12-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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7OX4
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7OX3
| Fab 6D3: hIL-9 complex | 分子名称: | Heavy chain (Fab 6D3), Interleukin-9, Light chain (Fab 6D3), ... | 著者 | De Vos, T, Savvides, S.N. | 登録日 | 2021-06-22 | 公開日 | 2022-12-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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7OX2
| Fab 6E2: hIL-9 complex | 分子名称: | Heavy chain (Fab 6E2), Interleukin-9, Light chain (Fab 6E2), ... | 著者 | De Vos, T, Savvides, S.N. | 登録日 | 2021-06-22 | 公開日 | 2022-12-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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7OX1
| Fab 7D6: hIL-9 complex | 分子名称: | Heavy chain (Fab 7D6), Interleukin-9, Light chain (Fab 7D6) | 著者 | De Vos, T, Savvides, S.N. | 登録日 | 2021-06-22 | 公開日 | 2022-12-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Biorxiv, 2022
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8AVD
| Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (4.42 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVO
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVF
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (6.45 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVC
| Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AV2
| Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ... | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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8AVE
| Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | 分子名称: | Leptin, Leptin receptor | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | 登録日 | 2022-08-26 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (5.62 Å) | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
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