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2BK5
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BU of 2bk5 by Molmil
Human Monoamine Oxidase B: I199F mutant in complex with isatin
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, ISATIN
著者Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N.
登録日2005-02-10
公開日2005-02-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors.
J.Biol.Chem., 280, 2005
2BK4
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Human Monoamine Oxidase B: I199F mutant in complex with rasagiline
分子名称: (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N.
登録日2005-02-10
公開日2005-02-14
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors
J.Biol.Chem., 280, 2005
1GOS
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BU of 1gos by Molmil
Human Monoamine Oxidase B
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, MONOAMINE OXIDASE, N-[(E)-METHYL](PHENYL)-N-[(E)-2-PROPENYLIDENE]METHANAMINIUM
著者Binda, C, Newton-Vinson, P, Hubalek, F, Edmondson, D.E, Mattevi, A.
登録日2001-10-26
公開日2001-11-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Human Monoamine Oxidase B, a Drug Target for the Treatment of Neurological Disorders
Nat.Struct.Biol., 9, 2001
2VRM
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BU of 2vrm by Molmil
Structure of human MAO B in complex with phenyethylhydrazine
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, PHENYLETHANE
著者Binda, C, Wang, J, Li, M, Hubalek, F, Mattevi, A, Edmondson, D.E.
登録日2008-04-09
公開日2008-04-22
最終更新日2014-01-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
Biochemistry, 47, 2008
2VRL
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BU of 2vrl by Molmil
Structure of human MAO B in complex with benzylhydrazine
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, TOLUENE
著者Binda, C, Wang, J, Li, M, Hubalek, F, Mattevi, A, Edmondson, D.E.
登録日2008-04-09
公開日2008-04-22
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
Biochemistry, 47, 2008
2C64
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BU of 2c64 by Molmil
MAO inhibition by rasagiline analogues
分子名称: (1R)-6-HYDROXY-N-METHYL-N-[(1Z)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
登録日2005-11-07
公開日2006-01-04
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C67
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MAO inhibition by rasagiline analogues
分子名称: AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-1(R)-AMINOINDAN
著者Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
登録日2005-11-07
公開日2006-01-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C66
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MAO inhibition by rasagiline analogues
分子名称: 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
登録日2005-11-07
公開日2006-01-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C65
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MAO inhibition by rasagiline analogues
分子名称: (1R)-4-({[ETHYL(METHYL)AMINO]CARBONYL}OXY)-N-METHYL-N-[(1E)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
登録日2005-11-07
公開日2006-01-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
8RRP
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BU of 8rrp by Molmil
Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin
分子名称: ACETATE ION, Insulin, Insulin B chain
著者Schluckebier, G, Johansson, E.
登録日2024-01-23
公開日2024-07-10
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec.
Nat Commun, 15, 2024
6S4J
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BU of 6s4j by Molmil
Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin
分子名称: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]
著者Johansson, E.
登録日2019-06-28
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular engineering of safe and efficacious oral basal insulin.
Nat Commun, 11, 2020
6S4I
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Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin
分子名称: Insulin, NITRATE ION
著者Johansson, E.
登録日2019-06-28
公開日2020-07-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.511 Å)
主引用文献Molecular engineering of safe and efficacious oral basal insulin.
Nat Commun, 11, 2020
2BK3
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BU of 2bk3 by Molmil
Human Monoamine Oxidase B in complex with Farnesol
分子名称: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Edmondson, D.E, Mattevi, A.
登録日2005-02-10
公開日2005-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.
J. Biol. Chem., 280, 2005
7NHU
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BU of 7nhu by Molmil
Crystal structure of desB30 insulin produced by cell free protein synthesis
分子名称: Insulin
著者Johansson, E.
登録日2021-02-11
公開日2021-06-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein.
Protein Expr.Purif., 186, 2021
4EFX
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BU of 4efx by Molmil
Highly biologically active insulin with additional disulfide bond
分子名称: Insulin, ZINC ION
著者Norrman, M, Vinther, T.N.
登録日2012-03-30
公開日2013-03-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Insulin analog with additional disulfide bond has increased stability and preserved activity.
Protein Sci., 22, 2013
5BTS
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BU of 5bts by Molmil
Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin
分子名称: Insulin A chain, Insulin B chain
著者Norrman, M, Hjorth, C.F.
登録日2015-06-03
公開日2016-03-09
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin.
J.Pharm.Sci., 105, 2016
3U4N
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BU of 3u4n by Molmil
A novel covalently linked insulin dimer
分子名称: Insulin A chain, Insulin B chain
著者Norrman, M, Vinther, T.N.
登録日2011-10-10
公開日2012-04-11
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
Plos One, 7, 2012
1OJC
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BU of 1ojc by Molmil
HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH N-(2-aminoethyl)-p-chlorobenzamide
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
著者Binda, C, Edmondson, D.E, Mattevi, A.
登録日2003-07-08
公開日2003-08-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJA
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ISATIN
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, ISATIN
著者Binda, C, Edmondson, D.E, Mattevi, A.
登録日2003-07-08
公開日2003-08-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJD
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BU of 1ojd by Molmil
HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH Lauryldimethylamine-N-oxide (LDAO)
分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, LAURYL DIMETHYLAMINE-N-OXIDE
著者Binda, C, Edmondson, D.E, Mattevi, A.
登録日2003-07-08
公開日2003-08-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJ9
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE
分子名称: 1,4-DIPHENYL-2-BUTENE, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
著者Binda, C, Edmondson, D.E, Mattevi, A.
登録日2003-07-08
公開日2003-08-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
8PI4
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BU of 8pi4 by Molmil
Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in dimer (T2) conformation
分子名称: Insulin B chain,Insulin A chain
著者Johansson, E, Schluckebier, G.
登録日2023-06-21
公開日2023-11-08
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PJH
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Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation
分子名称: Insulin
著者Schluckebier, G, Johansson, E.
登録日2023-06-23
公開日2023-11-08
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PI5
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BU of 8pi5 by Molmil
Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in hexamer (T3R3) conformation
分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, RESORCINOL, ...
著者Johansson, E, Schluckebier, G.
登録日2023-06-21
公開日2023-11-08
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PI6
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BU of 8pi6 by Molmil
Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension
分子名称: Insulin B chain,Insulin A chain
著者Johansson, E, Schluckebier, G.
登録日2023-06-21
公開日2023-11-08
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024

 

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