2BK4

Human Monoamine Oxidase B: I199F mutant in complex with rasagiline

Summary for 2BK4

• Entry DOI: 10.2210/pdb2bk4/pdb
• Related: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK5
• Descriptor: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, ... (4 entities in total)
• Functional Keywords: oxidoreductase, fad-containing amine oxidase, maob acetylation, fad, flavoprotein, maob, transmembrane
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• Total number of polymer chains: 2
• Total formula weight: 119661.10

Authors

Binda, C.,Edmondson, D.E.,Mattevi, A.,Hubalek, F.,Khalil, A.,Li, M.,Castagnoli, N. (deposition date: 2005-02-10, release date: 2005-02-14, Last modification date: 2023-12-13)

• Primary citation: Hubalek, F.,Binda, C.,Khalil, A.,Li, M.,Mattevi, A.,Castagnoli, N.,Edmondson, D.E.; Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors; J.Biol.Chem., 280:15761-, 2005; PubMed: 15710600; DOI: 10.1074/JBC.M500949200

Experimental method

X-RAY DIFFRACTION (1.9 Å)