2D5R
 
 | | Crystal Structure of a Tob-hCaf1 Complex | | 分子名称: | CCR4-NOT transcription complex subunit 7, Tob1 protein | | 著者 | Horiuchi, M, Suzuki, N.N, Muroya, N, Takahasi, K, Nishida, M, Yoshida, Y, Ikematsu, N, Nakamura, T, Kawamura-Tsuzuku, J, Yamamoto, T, Inagaki, F. | | 登録日 | 2005-11-04 | | 公開日 | 2006-12-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
J.Biol.Chem., 284, 2009
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1K1Z
 | | Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav | | 分子名称: | vav | | 著者 | Ogura, K, Nagata, K, Horiuchi, M, Ebisui, E, Hasuda, T, Yuzawa, S, Nishida, M, Hatanaka, H, Inagaki, F. | | 登録日 | 2001-09-26 | | 公開日 | 2001-10-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain
J.BIOMOL.NMR, 22, 2002
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3A77
 | | The crystal structure of phosphorylated IRF-3 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Interferon regulatory factor 3 | | 著者 | Takahasi, K, Horiuchi, M, Noda, N.N, Inagaki, F. | | 登録日 | 2009-09-17 | | 公開日 | 2010-08-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.
Genes Cells, 15, 2010
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6KXE
 | | The ishigamide ketosynthase/chain length factor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Ketosynthase, ... | | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | | 登録日 | 2019-09-10 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase.
Nat.Chem.Biol., 16, 2020
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6KXF
 | | The ishigamide ketosynthase/chain length factor | | 分子名称: | ACP, Ketosynthase, [(3~{R})-2,2-dimethyl-4-[[3-[2-[[(~{E})-oct-2-enoyl]amino]ethylamino]-3-oxidanylidene-propyl]amino]-3-oxidanyl-4-oxidanylidene-butyl] dihydrogen phosphate | | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | | 登録日 | 2019-09-10 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase.
Nat.Chem.Biol., 16, 2020
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6KXD
 | | The ishigamide ketosynthase/chain length factor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Ketosynthase, ... | | 著者 | Du, D, Katsuyama, Y, Horiuchi, M, Fushinobu, S, Chen, A, Davis, T, Burkart, M, Ohnishi, Y. | | 登録日 | 2019-09-10 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for selectivity in a highly reducing type II polyketide synthase.
Nat.Chem.Biol., 16, 2020
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2RQE
 | | Solution structure of the silkworm bGRP/GNBP3 N-terminal domain reveals the mechanism for b-1,3-glucan specific recognition | | 分子名称: | Beta-1,3-glucan-binding protein | | 著者 | Takahasi, K, Ochiai, M, Horiuchi, M, Kumeta, H, Ogura, K, Ashida, M, Inagaki, F. | | 登録日 | 2009-04-22 | | 公開日 | 2009-06-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the silkworm betaGRP/GNBP3 N-terminal domain reveals the mechanism for beta-1,3-glucan-specific recognition.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2RQA
 | | Solution structure of LGP2 CTD | | 分子名称: | ATP-dependent RNA helicase DHX58, ZINC ION | | 著者 | Takahasi, K, Kumeta, H, Tsuduki, N, Narita, R, Shigemoto, T, Hirai, R, Yoneyama, M, Horiuchi, M, Ogura, K, Fujita, T, Fuyuhiko, I. | | 登録日 | 2009-03-17 | | 公開日 | 2009-05-05 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS
J.Biol.Chem., 284, 2009
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2RQB
 | | Solution structure of MDA5 CTD | | 分子名称: | Interferon-induced helicase C domain-containing protein 1, ZINC ION | | 著者 | Takahasi, K, Kumeta, H, Tsuduki, N, Narita, R, Shigemoto, T, Hirai, R, Yoneyama, M, Horiuchi, M, Ogura, K, Fujita, T, Fuyuhiko, I. | | 登録日 | 2009-03-17 | | 公開日 | 2009-05-05 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS
J.Biol.Chem., 284, 2009
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1WMH
 | | Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha | | 分子名称: | Partitioning defective-6 homolog alpha, Protein kinase C, iota type | | 著者 | Hirano, Y, Yoshinaga, S, Suzuki, N.N, Horiuchi, M, Kohjima, M, Takeya, R, Sumimoto, H, Inagaki, F. | | 登録日 | 2004-07-09 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of a Cell Polarity Regulator, a Complex between Atypical PKC and Par6 PB1 Domains
J.Biol.Chem., 280, 2005
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2M1X
 | | TICAM-1 TIR domain structure | | 分子名称: | TIR domain-containing adapter molecule 1 | | 著者 | Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F. | | 登録日 | 2012-12-07 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2CZO
 | | Solution Structure of the PX Domain of Bem1p | | 分子名称: | Bud emergence protein 1 | | 著者 | Maeda, A, Ogura, K, Horiuchi, M, Kumeta, H, Fujioka, Y, Inagaki, F. | | 登録日 | 2005-07-14 | | 公開日 | 2006-10-03 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the PX domain of Bem1p
To be Published
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2M1W
 | | TICAM-2 TIR domain | | 分子名称: | TIR domain-containing adapter molecule 2 | | 著者 | Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F. | | 登録日 | 2012-12-07 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
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1J2F
 | | X-ray crystal structure of IRF-3 and its functional implications | | 分子名称: | Interferon regulatory factor 3 | | 著者 | Takahasi, K, Noda, N, Horiuchi, M, Mori, M, Okabe, Y, Fukuhara, Y, Terasawa, H, Fujita, T, Inagaki, F. | | 登録日 | 2003-01-04 | | 公開日 | 2003-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystal structure of IRF-3 and its functional implications.
Nat.Struct.Biol., 10, 2003
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1UCF
 | | The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease | | 分子名称: | RNA-binding protein regulatory subunit | | 著者 | Honbou, K, Suzuki, N.N, Horiuchi, M, Niki, T, Taira, T, Ariga, H, Inagaki, F. | | 登録日 | 2003-04-11 | | 公開日 | 2003-08-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease
J.BIOL.CHEM., 278, 2003
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1WLZ
 | | Crystal structure of DJBP fragment which was obtained by limited proteolysis | | 分子名称: | CAP-binding protein complex interacting protein 1 isoform a | | 著者 | Honbou, K, Suzuki, N, Horiuchi, M, Taira, T, Niki, T, Ariga, H, Inagaki, F. | | 登録日 | 2004-07-01 | | 公開日 | 2005-08-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of DJBP Fragment which was obtained by Limited Proteolysis
To be Published
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8CXR
 | | Crystal structure of MraY bound to a sphaerimicin analogue | | 分子名称: | (1S,4R,5S,6R,7S,9S,10S,11S,13S,14R)-9-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]-14-(hexadecanoyloxy)-5,6,13-trihydroxy-8,16-dioxa-2,11-diazatricyclo[9.3.1.1~4,7~]hexadecane-10-carboxylic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | | 著者 | Mashalidis, E.H, Lee, S.Y. | | 登録日 | 2022-05-22 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.
Nat Commun, 13, 2022
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3WCK
 | | Crystal structure of monomeric photosensitizing fluorescent protein, Supernova | | 分子名称: | Monomeric photosenitizing fluorescent protein supernova | | 著者 | Sakai, N, Matsuda, T, Takemoto, K, Nagai, T. | | 登録日 | 2013-05-27 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation
Sci Rep, 3, 2013
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9B71
 | | Cryo-EM structure of MraY in complex with analogue 3 | | 分子名称: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]-2-[[4-[[[(2~{S})-5-carbamimidamido-2-(hexadecanoylamino)pentanoyl]amino]methyl]phenyl]methylamino]propanoic acid, MraYAA Nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | | 著者 | Hao, A, Lee, S.-Y. | | 登録日 | 2024-03-26 | | 公開日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.
Nat Commun, 15, 2024
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9B70
 | | Cryo-EM structure of MraY in complex with analogue 2 | | 分子名称: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-2-[[3-[[[(2~{S})-6-azanyl-2-(hexadecanoylamino)hexanoyl]amino]methyl]phenyl]methylamino]-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propanoic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | | 著者 | Hao, A, Lee, S.-Y. | | 登録日 | 2024-03-26 | | 公開日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.
Nat Commun, 15, 2024
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2R6N
 | | Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K | | 分子名称: | 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine, Cathepsin K | | 著者 | Cowan-Jacob, S.W, Ramage, P, Mathis, B, Geisse, S. | | 登録日 | 2007-09-06 | | 公開日 | 2007-11-06 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Novel scaffold for cathepsin K inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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1GCQ
 | | CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, VAV PROTO-ONCOGENE | | 著者 | Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F. | | 登録日 | 2000-08-08 | | 公開日 | 2001-08-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Novel recognition mode between Vav and Grb2 SH3 domains.
EMBO J., 20, 2001
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1GCP
 | | CRYSTAL STRUCTURE OF VAV SH3 DOMAIN | | 分子名称: | VAV PROTO-ONCOGENE | | 著者 | Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F. | | 登録日 | 2000-08-08 | | 公開日 | 2001-08-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Novel recognition mode between Vav and Grb2 SH3 domains.
EMBO J., 20, 2001
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2M63
 | | The protease-resistant N-terminal domain of TIR-domain containing adaptor molecule-1, TICAM-1 | | 分子名称: | TIR domain-containing adapter molecule 1 | | 著者 | Kumeta, H, Enokizono, Y, Sakakibara, H, Ogura, K, Matsumoto, M, Seya, T, Inagaki, F. | | 登録日 | 2013-03-20 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.
J.Biomol.Nmr, 58, 2014
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1UAW
 | | Solution structure of the N-terminal RNA-binding domain of mouse Musashi1 | | 分子名称: | mouse-musashi-1 | | 著者 | Miyanoiri, Y, Kobayashi, H, Watanabe, M, Ikeda, T, Nagata, T, Okano, H, Uesugi, S, Katahira, M. | | 登録日 | 2003-03-24 | | 公開日 | 2004-03-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics
J.Biol.Chem., 278, 2003
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