8CXR
Crystal structure of MraY bound to a sphaerimicin analogue
Summary for 8CXR
Entry DOI | 10.2210/pdb8cxr/pdb |
Descriptor | MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (1S,4R,5S,6R,7S,9S,10S,11S,13S,14R)-9-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]-14-(hexadecanoyloxy)-5,6,13-trihydroxy-8,16-dioxa-2,11-diazatricyclo[9.3.1.1~4,7~]hexadecane-10-carboxylic acid (3 entities in total) |
Functional Keywords | mray, nanobody, sphaerimicin, membrane protein, membrane protein-transferase complex, membrane protein/transferase |
Biological source | Lama glama More |
Total number of polymer chains | 8 |
Total formula weight | 225619.12 |
Authors | Mashalidis, E.H.,Lee, S.Y. (deposition date: 2022-05-22, release date: 2023-03-29, Last modification date: 2023-10-25) |
Primary citation | Nakaya, T.,Yabe, M.,Mashalidis, E.H.,Sato, T.,Yamamoto, K.,Hikiji, Y.,Katsuyama, A.,Shinohara, M.,Minato, Y.,Takahashi, S.,Horiuchi, M.,Yokota, S.I.,Lee, S.Y.,Ichikawa, S. Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY. Nat Commun, 13:7575-7575, 2022 Cited by PubMed: 36539416DOI: 10.1038/s41467-022-35227-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.65 Å) |
Structure validation
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