9B71

Cryo-EM structure of MraY in complex with analogue 3

This is a non-PDB format compatible entry.

Summary for 9B71

• Entry DOI: 10.2210/pdb9b71/pdb
• Related: 9B70
• EMDB information: 44294
• Descriptor: MraYAA Nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]-2-[[4-[[[(2~{S})-5-carbamimidamido-2-(hexadecanoylamino)pentanoyl]amino]methyl]phenyl]methylamino]propanoic acid, ... (4 entities in total)
• Functional Keywords: inhibitor, antibiotics, transferase
• Biological source: Lama glama (llama); More
• Total number of polymer chains: 4
• Total formula weight: 113948.95

Authors

Hao, A.,Lee, S.-Y. (deposition date: 2024-03-26, release date: 2024-06-26)

• Primary citation: Yamamoto, K.,Sato, T.,Hao, A.,Asao, K.,Kaguchi, R.,Kusaka, S.,Ruddarraju, R.R.,Kazamori, D.,Seo, K.,Takahashi, S.,Horiuchi, M.,Yokota, S.I.,Lee, S.Y.,Ichikawa, S.; Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.; Nat Commun, 15:5085-5085, 2024; PubMed: 38877016; DOI: 10.1038/s41467-024-49484-7

Experimental method