2R6N
Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K
Summary for 2R6N
Entry DOI | 10.2210/pdb2r6n/pdb |
Related | 1U9V 1U9W 1U9X |
Descriptor | Cathepsin K, 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (3 entities in total) |
Functional Keywords | covalent bond to inhibitor, disease mutation, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24156.31 |
Authors | Cowan-Jacob, S.W.,Ramage, P.,Mathis, B.,Geisse, S. (deposition date: 2007-09-06, release date: 2007-11-06, Last modification date: 2017-10-25) |
Primary citation | Teno, N.,Miyake, T.,Ehara, T.,Irie, O.,Sakaki, J.,Ohmori, O.,Gunji, H.,Matsuura, N.,Masuya, K.,Hitomi, Y.,Nonomura, K.,Horiuchi, M.,Gohda, K.,Iwasaki, A.,Umemura, I.,Tada, S.,Kometani, M.,Iwasaki, G.,Cowan-Jacob, S.W.,Missbach, M.,Lattmann, R.,Betschart, C. Novel scaffold for cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 17:6096-6100, 2007 Cited by PubMed: 17911019DOI: 10.1016/j.bmcl.2007.09.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report