1ZFD
 
 | | SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES | | 分子名称: | SWI5, ZINC ION | | 著者 | Neuhaus, D, Nakaseko, Y, Schwabe, J.W.R, Rhodes, D, Klug, A. | | 登録日 | 1996-04-04 | | 公開日 | 1996-10-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet.
J.Mol.Biol., 228, 1992
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1Q1P
 | | E-Cadherin activation | | 分子名称: | CALCIUM ION, Epithelial-cadherin | | 著者 | Haussinger, D, Stetefeld, J. | | 登録日 | 2003-07-22 | | 公開日 | 2004-04-20 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
Embo J., 23, 2004
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3ZDV
 | | Crystal structure of the LecB lectin from Pseudomonas aeruginosa in complex with Methyl 6-(2,4,6-trimethylphenylsulfonylamido)-6-deoxy-alpha-D-mannopyranoside | | 分子名称: | 1,2-ETHANEDIOL, 2,4,6-trimethylbenzenesulfonamide, CALCIUM ION, ... | | 著者 | Hauck, D, Joachim, I, Frommeyer, B, Varrot, A, Philipp, B, MOller, H.M, Imberty, A, Exner, T.E, Titz, A. | | 登録日 | 2012-11-30 | | 公開日 | 2013-09-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas Aeruginosa Lecb with Distinct Binding Modes.
Acs Chem.Biol., 8, 2013
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8RD5
 | | Crystal structure of Kemp Eliminase HG3.R5 with bound transition state analog 6-nitrobenzotriazole | | 分子名称: | 6-NITROBENZOTRIAZOLE, ACETATE ION, Endo-1,4-beta-xylanase, ... | | 著者 | Schaub, D, Schwander, T, Hueppi, S, Buller, R.M. | | 登録日 | 2023-12-07 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Enriching productive mutational paths accelerates enzyme evolution.
Nat.Chem.Biol., 2024
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2L31
 | | Human PARP-1 zinc finger 2 | | 分子名称: | Poly [ADP-ribose] polymerase 1, ZINC ION | | 著者 | Neuhaus, D, Eustermann, S, Yang, J, Videler, H. | | 登録日 | 2010-08-30 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
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2L30
 | | Human PARP-1 zinc finger 1 | | 分子名称: | Poly [ADP-ribose] polymerase 1, ZINC ION | | 著者 | Neuhaus, D, Eustermann, S, Yang, J, Videler, H. | | 登録日 | 2010-08-30 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger.
J.Mol.Biol., 407, 2011
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2LD1
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2KQC
 | | Second PBZ domain of human APLF protein | | 分子名称: | Aprataxin and PNK-like factor, ZINC ION | | 著者 | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | | 登録日 | 2009-11-04 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
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2KQB
 | | First PBZ domain of human APLF protein | | 分子名称: | Aprataxin and PNK-like factor, ZINC ION | | 著者 | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | | 登録日 | 2009-11-04 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
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2KQD
 | | First PBZ domain of human APLF protein in complex with ribofuranosyladenosine | | 分子名称: | ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ... | | 著者 | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | | 登録日 | 2009-11-04 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
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2KQE
 | | Second PBZ domain of human APLF protein in complex with ribofuranosyladenosine | | 分子名称: | ADENOSINE, Aprataxin and PNK-like factor, ZINC ION, ... | | 著者 | Neuhaus, D, Eustermann, S, Brockmann, C, Yang, J. | | 登録日 | 2009-11-04 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Nat.Struct.Mol.Biol., 17, 2010
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5NR6
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5NR5
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7MLA
 | | Solution NMR structure of HDMX in complex with Zn and MCo-52-2 | | 分子名称: | MCo-52-2, Protein Mdm4, ZINC ION | | 著者 | Ramirez, L.S, Theophall, G, Chaudhuri, D, Camarero, J.C, Shekhtman, A. | | 登録日 | 2021-04-28 | | 公開日 | 2022-05-04 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of HDMX in complex with Zn and cyclotide 52-2
To Be Published
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2N8A
 | | 1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break | | 分子名称: | DNA (45-MER), Poly [ADP-ribose] polymerase 1, ZINC ION | | 著者 | Neuhaus, D, Eustermann, S, Yang, J, Wu, W. | | 登録日 | 2015-10-08 | | 公開日 | 2015-12-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Mol.Cell, 60, 2015
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2LH8
 | | Syrian hamster prion protein with thiamine | | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Major prion protein | | 著者 | Perez-Pineiro, R, Bjorndahl, T.C, Berjanskii, M, Hau, D, Li, L, Huang, A, Lee, R, Gibbs, E, Ladner, C, Wei Dong, Y, Abera, A, Cashman, N.R, Wishart, D. | | 登録日 | 2011-08-05 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The prion protein binds thiamine.
Febs J., 278, 2011
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7AAB
 | | Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 | | 分子名称: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | | 著者 | Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. | | 登録日 | 2020-09-04 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
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7AAA
 | | Crystal structure of the catalytic domain of human PARP1 (apo) | | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ... | | 著者 | Schimpl, M, Ogden, T.E.H, Yang, J.-C, Underwood, E, Rawlins, P.B, Johannes, J.W, Easton, L.E, Embrey, K.J, Neuhaus, D. | | 登録日 | 2020-09-04 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
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1AUD
 | | U1A-UTRRNA, NMR, 31 STRUCTURES | | 分子名称: | RNA 3UTR, U1A 102 | | 著者 | Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G. | | 登録日 | 1997-08-22 | | 公開日 | 1998-02-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis of the RNA-binding specificity of human U1A protein.
EMBO J., 16, 1997
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1NCS
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1CDQ
 | | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | | 分子名称: | CD59 | | 著者 | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | | 登録日 | 1994-06-01 | | 公開日 | 1994-09-30 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.
Structure, 2, 1994
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1CDR
 | | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 | | 著者 | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | | 登録日 | 1994-06-01 | | 公開日 | 1994-09-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.
Structure, 2, 1994
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1CDS
 | | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 | | 著者 | Fletcher, C.M, Harrison, R.A, Lachmann, P.J, Neuhaus, D. | | 登録日 | 1994-06-01 | | 公開日 | 1994-09-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.
Structure, 2, 1994
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5A8Y
 | | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, MALONATE ION, ... | | 著者 | vonNussbaum, F, Li, V.M, Meibom, D, Anlauf, S, Bechem, M, Delbeck, M, Gerisch, M, Harrenga, A, Karthaus, D, Lang, D, Lustig, K, Mittendorf, J, Schaefer, M, Schaefer, S, Schamberger, J. | | 登録日 | 2015-07-17 | | 公開日 | 2016-08-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: In Vivo Efficacy of the Polar Pyrimidopyridazine Bay-8040 in a Pulmonary Arterial Hypertension Rat Model.
Chemmedchem, 11, 2016
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5A0A
 | | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile, ... | | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | | 登録日 | 2015-04-17 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases.
ChemMedChem, 10, 2015
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