5A8Y

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Summary for 5A8Y

Entry DOI	10.2210/pdb5a8y/pdb
Related	5A8X 5A8Z
Descriptor	NEUTROPHIL ELASTASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	trypsin family fold, protease, hydrolase, hydrolase-inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	25033.57
Authors	vonNussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schaefer, M.,Schaefer, S.,Schamberger, J. (deposition date: 2015-07-17, release date: 2016-08-03, Last modification date: 2020-07-29)
Primary citation	Von Nussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schafer, M.,Schafer, S.,Schamberger, J. Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: In Vivo Efficacy of the Polar Pyrimidopyridazine Bay-8040 in a Pulmonary Arterial Hypertension Rat Model. Chemmedchem, 11:199-, 2016 Cited by PubMed: 26333652 DOI: 10.1002/CMDC.201500269 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation