5A8Y
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NEUTROPHIL ELASTASE | polymer | 218 | 23319.0 | 1 | UniProt (P08246) Pfam (PF00089) In PDB | HOMO SAPIENS (HUMAN) | BONE MARROW SERINE PROTEASE, ELASTASE-2, HUMAN LEUKOCYTE ELASTASE, HLE, MEDULLASIN, PMN ELASTASE |
| 2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 4 | A | METHYL {(7R)-6-CYANO-7-(4-CYANOPHENYL)-5-METHYL-4-[3-(TRIFLUOROMETHYL)PHENYL]-4,7-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL}CARBAMATE | non-polymer | 479.4 | 1 | Chemie (VBM) | |||
| 5 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | A | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 7 | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23319.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 937.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 776.7 | |
| All* | Total formula weight | 25033.6 |
