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5A8X

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Summary for 5A8X
Entry DOI10.2210/pdb5a8x/pdb
Related5A8Y 5A8Z
DescriptorNeutrophil elastase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordstrypsin family fold, protease, hydrolase, hydrolase- inhibitor complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight24728.32
Authors
Primary citationvon Nussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schafer, M.,Schafer, S.,Schamberger, J.
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
ChemMedChem, 11:199-206, 2016
Cited by
PubMed: 26333652
DOI: 10.1002/cmdc.201500269
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.23 Å)
Structure validation

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