5A8X
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neutrophil elastase | polymer | 218 | 23319.0 | 1 | UniProt (P08246) Pfam (PF00089) | Homo sapiens (Human) | Bone marrow serine protease,Elastase-2,Human leukocyte elastase,HLE,Medullasin,PMN elastase |
| 2 | B, C (B, C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 3 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | E (A) | ethyl (5R)-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-1,5-dihydroimidazo[1,2-a]pyrimidin-4-ium-6-carboxylate | non-polymer | 453.4 | 1 | Chemie (IUY) | |||
| 5 | F (A) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23319.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 734.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 674.6 | |
| All* | Total formula weight | 24728.3 |
