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5A8X

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001878biological_processresponse to yeast
A0002020molecular_functionprotease binding
A0002438biological_processacute inflammatory response to antigenic stimulus
A0002523biological_processleukocyte migration involved in inflammatory response
A0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
A0003714molecular_functiontranscription corepressor activity
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006874biological_processintracellular calcium ion homeostasis
A0006909biological_processphagocytosis
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009411biological_processresponse to UV
A0009986cellular_componentcell surface
A0017053cellular_componenttranscription repressor complex
A0019955molecular_functioncytokine binding
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030163biological_processprotein catabolic process
A0031410cellular_componentcytoplasmic vesicle
A0032496biological_processresponse to lipopolysaccharide
A0032682biological_processnegative regulation of chemokine production
A0032717biological_processnegative regulation of interleukin-8 production
A0032757biological_processpositive regulation of interleukin-8 production
A0035578cellular_componentazurophil granule lumen
A0035580cellular_componentspecific granule lumen
A0042742biological_processdefense response to bacterium
A0043406biological_processpositive regulation of MAP kinase activity
A0045335cellular_componentphagocytic vesicle
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050778biological_processpositive regulation of immune response
A0050832biological_processdefense response to fungus
A0050900biological_processleukocyte migration
A0050922biological_processnegative regulation of chemotaxis
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070269biological_processpyroptotic inflammatory response
A0070945biological_processneutrophil-mediated killing of gram-negative bacterium
A0070947biological_processneutrophil-mediated killing of fungus
A1903238biological_processpositive regulation of leukocyte tethering or rolling
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSAAHC
ChainResidueDetails
AMET53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. GVcfGDSGSPLV
ChainResidueDetails
AGLY189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:2911584
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN72

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26274980, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN109

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN159

227111

PDB entries from 2024-11-06

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