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1RV6
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BU of 1rv6 by Molmil
Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FLT1 protein, placenta growth factor (PlGF)
著者Christinger, H.W, Fuh, G, de Vos, A.M, Wiesmann, C.
登録日2003-12-12
公開日2004-01-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1CZ8
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
分子名称: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
著者Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
登録日1999-09-01
公開日2000-03-20
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1D0G
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BU of 1d0g by Molmil
CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL
分子名称: APOPTOSIS-2 LIGAND, CHLORIDE ION, DEATH RECEPTOR-5, ...
著者Hymowitz, S.G, Christinger, H.W, Fuh, G, O'Connell, M.P, Kelley, R.F, Ashkenazi, A, de Vos, A.M.
登録日1999-09-09
公開日1999-10-22
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
Mol.Cell, 4, 1999
2FJG
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BU of 2fjg by Molmil
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJF
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BU of 2fjf by Molmil
Structure of the G6 Fab, a phage derived VEGF binding Fab
分子名称: Heavy Chain of a VEGF binding Antibody, Light Chain of a VEGF binding Antibody
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJH
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BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
5VZX
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BU of 5vzx by Molmil
Crystal structure of crenezumab Fab
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Crenezumab Fab heavy chain, ...
著者Ultsch, M, Wang, W.
登録日2017-05-29
公開日2017-08-09
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin.
Sci Rep, 6, 2016
5VZY
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Crystal structure of crenezumab Fab in complex with Abeta
分子名称: Amyloid beta A4 protein, Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain
著者Ultsch, M, Wang, W.
登録日2017-05-29
公開日2017-08-09
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin.
Sci Rep, 6, 2016
3P0Y
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BU of 3p0y by Molmil
anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P0V
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anti-EGFR/HER3 Fab DL11 alone
分子名称: CALCIUM ION, Fab DL11 heavy chain, Fab DL11 light chain
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-19
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P11
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anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab DL11 heavy chain, ...
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3BE1
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BU of 3be1 by Molmil
Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Fragment-Heavy Chain, ...
著者Bostrom, J.M, Wiesmann, C, Appleton, B.A.
登録日2007-11-15
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
3BDY
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BU of 3bdy by Molmil
Dual specific bH1 Fab in complex with VEGF
分子名称: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ...
著者Bostrom, J.M, Wiesmann, C, Appleton, B.A.
登録日2007-11-15
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
4ZFF
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Dual-acting Fab 5A12 in complex with VEGF
分子名称: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
著者Harris, S.F, Wu, P.
登録日2015-04-21
公開日2015-07-01
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
4ZFG
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BU of 4zfg by Molmil
Dual-specificity Fab 5A12 in complex with Angiopoietin 2
分子名称: Angiopoietin-2, CALCIUM ION, Fragment antigen binding 5A12 heavy chain, ...
著者Harris, S.F, Wu, P.
登録日2015-04-21
公開日2015-07-01
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
1FLT
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BU of 1flt by Molmil
VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, De Vos, A.M.
登録日1997-11-20
公開日1999-01-13
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
2HFF
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BU of 2hff by Molmil
Crystal structure of CB2 Fab
分子名称: CB2 Fab, heavy chain, light chain
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
2HFG
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Crystal structure of hBR3 bound to CB3s-Fab
分子名称: CB3s Fab heavy chain, CB3s Fab light chain (kappa), Tumor necrosis factor receptor superfamily member 13C
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
1QTY
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
著者Wiesmann, C, de Vos, A.M.
登録日1999-06-29
公開日2000-01-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1TZI
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Crystal Structure of the Fab YADS2 Complexed with h-VEGF
分子名称: Fab YADS2 Heavy Chain, Fab YADS2 Light Chain, Vascular endothelial growth factor A
著者Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
登録日2004-07-10
公開日2004-08-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZH
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Crystal Structure of the Fab YADS1 Complexed with h-VEGF
分子名称: Fab YADS1 Heavy Chain, Fab YADS1 Light Chain, Vascular endothelial growth factor A
著者Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
登録日2004-07-09
公開日2004-08-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004

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