4QXG
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2QL1
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![BU of 2ql1 by Molmil](/molmil-images/mine/2ql1) | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | 分子名称: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | 登録日 | 2007-07-12 | 公開日 | 2008-04-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.534 Å) | 主引用文献 | Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
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3C2S
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![BU of 3c2s by Molmil](/molmil-images/mine/3c2s) | Structural Characterization of a Human Fc Fragment Engineered for Lack of Effector Functions | 分子名称: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | 登録日 | 2008-01-25 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural characterization of a human Fc fragment engineered for lack of effector functions. Acta Crystallogr.,Sect.D, 64, 2008
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4U6V
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![BU of 4u6v by Molmil](/molmil-images/mine/4u6v) | Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | 分子名称: | Alpha-hemolysin, Fab, antigen binding fragment, ... | 著者 | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | 登録日 | 2014-07-29 | 公開日 | 2014-09-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody. J.Biol.Chem., 289, 2014
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5HVW
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![BU of 5hvw by Molmil](/molmil-images/mine/5hvw) | Monomeric IgG4 Fc | 分子名称: | GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ... | 著者 | Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F. | 登録日 | 2016-01-28 | 公開日 | 2016-08-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Generation and Characterization of an IgG4 Monomeric Fc Platform. Plos One, 11, 2016
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3SKJ
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![BU of 3skj by Molmil](/molmil-images/mine/3skj) | Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody | 分子名称: | Antibody, heavy chain, light chain, ... | 著者 | Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F. | 登録日 | 2011-06-22 | 公開日 | 2011-08-31 | 最終更新日 | 2017-05-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody. J.Mol.Biol., 413, 2011
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6WMH
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6WNA
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![BU of 6wna by Molmil](/molmil-images/mine/6wna) | Next generation monomeric IgG4 Fc | 分子名称: | Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Immunoglobulin heavy constant gamma 4, ... | 著者 | Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F. | 登録日 | 2020-04-22 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4, 2021
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6WOL
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![BU of 6wol by Molmil](/molmil-images/mine/6wol) | Next generation monomeric IgG4 Fc bound to neonatal Fc receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, IgG receptor FcRn large subunit p51, ... | 著者 | Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F. | 登録日 | 2020-04-24 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4, 2021
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3FJT
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![BU of 3fjt by Molmil](/molmil-images/mine/3fjt) | Crystal structure of a human Fc fragment engineered for extended serum half-life | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | 登録日 | 2008-12-15 | 公開日 | 2009-03-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural characterization of a human Fc fragment engineered for extended serum half-life. Mol.Immunol., 46, 2009
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4ZNE
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![BU of 4zne by Molmil](/molmil-images/mine/4zne) | IgG1 Fc-FcgammaRI ecd complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Oganesyan, V.Y, Dall'Acqua, W.F. | 登録日 | 2015-05-04 | 公開日 | 2015-11-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural insights into the interaction of human IgG1 with Fc gamma RI: no direct role of glycans in binding. Acta Crystallogr.,Sect.D, 71, 2015
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4YPG
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4N0F
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4N0U
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![BU of 4n0u by Molmil](/molmil-images/mine/4n0u) | Ternary complex between Neonatal Fc receptor, serum albumin and Fc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ... | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | 登録日 | 2013-10-02 | 公開日 | 2014-02-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms. J.Biol.Chem., 289, 2014
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4UB0
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6WIB
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![BU of 6wib by Molmil](/molmil-images/mine/6wib) | Next generation monomeric IgG4 Fc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 4, ZINC ION | 著者 | Oganesyan, V.Y, Shan, L, Dall'Acqua, W, van Dyk, N. | 登録日 | 2020-04-09 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4, 2021
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6ATT
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![BU of 6att by Molmil](/molmil-images/mine/6att) | 39S Fab bound to HER2 ecd | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 39S Fab heavy chain, ... | 著者 | Oganesyan, V.Y, Dall'Acqua, W.F. | 登録日 | 2017-08-29 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.77 Å) | 主引用文献 | Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody. J. Biol. Chem., 293, 2018
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6BRB
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![BU of 6brb by Molmil](/molmil-images/mine/6brb) | Novel non-antibody protein scaffold targeting CD40L | 分子名称: | CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. | 登録日 | 2017-11-30 | 公開日 | 2018-12-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019
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