2QL1

Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment

Summary for 2QL1

Entry DOI	10.2210/pdb2ql1/pdb
Descriptor	IGHM protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
Functional Keywords	antibody, adcc, fc fragment, mutation, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	27341.92
Authors	Oganesyan, V.,Wu, H.,Dall'Acqua, W.F. (deposition date: 2007-07-12, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Oganesyan, V.,Damschroder, M.M.,Leach, W.,Wu, H.,Dall'Acqua, W.F. Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45:1872-1882, 2008 Cited by PubMed: 18078997 DOI: 10.1016/j.molimm.2007.10.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.534 Å)

Structure validation