2QL1
Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | IGHM protein | polymer | 225 | 25454.8 | 1 | UniProt (Q6PJF1) Pfam (PF07654) UniProt (by SIFTS) (P01857) | Homo sapiens (human) | |
| 2 | B (C) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 3 | C, D, E, F (A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 223 - 447 (UniProt: Q6PJF1)
| PDB | External Database | Details |
|---|---|---|
| Asp 239 | Ser 272 | engineered mutation |
| Leu 330 | Ala 363 | engineered mutation |
| Glu 332 | Ile 365 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25454.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1625.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 27341.9 |
