6WNA

Next generation monomeric IgG4 Fc

Summary for 6WNA

• Entry DOI: 10.2210/pdb6wna/pdb
• Descriptor: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, Immunoglobulin heavy constant gamma 4, ... (5 entities in total)
• Functional Keywords: antibody constant region, fragment crystallizable, mutated, immune system, neonatal receptor interaction, half-life
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 66595.43

Authors

Oganesyan, V.Y.,Shan, L.,van Dyk, N.,Dall'Acqua, W.F. (deposition date: 2020-04-22, release date: 2021-09-15, Last modification date: 2023-10-18)

• Primary citation: Shan, L.,Dyk, N.V.,Haskins, N.,Cook, K.M.,Rosenthal, K.L.,Mazor, R.,Dragulin-Otto, S.,Jiang, Y.,Wu, H.,Dall'Acqua, W.F.,Borrok, M.J.,Damschroder, M.M.,Oganesyan, V.; In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.; Commun Biol, 4:1048-1048, 2021; PubMed: 34497355; DOI: 10.1038/s42003-021-02565-5

Experimental method

X-RAY DIFFRACTION (2.4 Å)