6WNA
Next generation monomeric IgG4 Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | IgG receptor FcRn large subunit p51 | polymer | 264 | 29433.1 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (H) | Immunoglobulin heavy constant gamma 4 | polymer | 207 | 23788.7 | 1 | UniProt (P01861) Pfam (PF07654) | Homo sapiens (Human) | Ig gamma-4 chain C region |
| 4 | D (C) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 5 | E, F, G (A, B, H) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
H: 238 - 444 (UniProt: P01861)
| PDB | External Database | Details |
|---|---|---|
| Tyr 252 | Met 132 | engineered mutation |
| Thr 254 | Ser 134 | engineered mutation |
| Glu 256 | Thr 136 | engineered mutation |
| Phe 351 | Leu 231 | engineered mutation |
| Glu 354 | Ser 234 | engineered mutation |
| Arg 366 | Thr 246 | engineered mutation |
| Lys 395 | Pro 275 | engineered mutation |
| Arg 405 | Phe 285 | engineered mutation |
| Glu 407 | Tyr 287 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64969.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1625.5 | |
| All* | Total formula weight | 66595.4 |
