6WOL

Next generation monomeric IgG4 Fc bound to neonatal Fc receptor

Summary for 6WOL

Entry DOI	10.2210/pdb6wol/pdb
Descriptor	Immunoglobulin heavy constant gamma 4, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (5 entities in total)
Functional Keywords	antibody constant region, fragment crystallizable, mutated, immune system, neonatal fc receptor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	66685.69
Authors	Oganesyan, V.Y.,Shan, L.,van Dyk, N.,Dall'Acqua, W.F. (deposition date: 2020-04-24, release date: 2021-09-15, Last modification date: 2023-10-18)
Primary citation	Shan, L.,Dyk, N.V.,Haskins, N.,Cook, K.M.,Rosenthal, K.L.,Mazor, R.,Dragulin-Otto, S.,Jiang, Y.,Wu, H.,Dall'Acqua, W.F.,Borrok, M.J.,Damschroder, M.M.,Oganesyan, V. In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance. Commun Biol, 4:1048-1048, 2021 Cited by PubMed: 34497355 DOI: 10.1038/s42003-021-02565-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation