6WOL

Next generation monomeric IgG4 Fc bound to neonatal Fc receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Immunoglobulin heavy constant gamma 4	polymer	209	23753.8	1	UniProt (P01861) Pfam (PF07654) In PDB	Homo sapiens (Human)	Ig gamma-4 chain C region
2	A	IgG receptor FcRn large subunit p51	polymer	267	29720.4	1	UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (Human)	FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor
3	B	Beta-2-microglobulin	polymer	99	11748.2	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	1	In PDB GlyTouCan (G59451NL)
5		water	water		18.0	33	Chemie (HOH)

Sequence modifications

H: 237 - 445 (UniProt: P01861)

PDB	External Database	Details
Phe 351	Leu 231	engineered mutation
Glu 354	Ser 234	engineered mutation
Arg 366	Thr 246	engineered mutation
Lys 395	Pro 275	engineered mutation
Arg 405	Phe 285	engineered mutation
Glu 407	Tyr 287	engineered mutation
Cys 432	Leu 312	engineered mutation
Ser 433	His 313	engineered mutation
Tyr 434	Asn 314	engineered mutation
Leu 436	Tyr 316	engineered mutation
Cys 437	Thr 317	engineered mutation
-	Gln 318	deletion

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	65222.3
Branched	Number of molecules	1
	Total formula weight	1463.3
All*	Total formula weight	66685.7

*Water molecules are not included.