3C2S

Structural Characterization of a Human Fc Fragment Engineered for Lack of Effector Functions

Summary for 3C2S

• Entry DOI: 10.2210/pdb3c2s/pdb
• Descriptor: IGHM protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• Functional Keywords: fc fragment, mutant, effector function, receptor, protein binding, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 27295.81

Authors

Oganesyan, V.,Wu, H.,Dall'Acqua, W.F. (deposition date: 2008-01-25, release date: 2008-08-19, Last modification date: 2023-08-30)

• Primary citation: Oganesyan, V.,Gao, C.,Shirinian, L.,Wu, H.,Dall'Acqua, W.F.; Structural characterization of a human Fc fragment engineered for lack of effector functions.; Acta Crystallogr.,Sect.D, 64:700-704, 2008; PubMed: 18560159; DOI: 10.1107/S0907444908007877

Experimental method

X-RAY DIFFRACTION (2.3 Å)