4QXG
Antigen binding fragment of an anti IFNAR1 antibody
Summary for 4QXG
Entry DOI | 10.2210/pdb4qxg/pdb |
Descriptor | Fab, heavy chain, IgG1, Fab, light chain, IgG1, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | igv and igc type folds, antigen binding, ifnar1, interferon alpha receptor 1, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 47243.67 |
Authors | Oganesyan, V.Y.,Dall'Acqua, W.F. (deposition date: 2014-07-20, release date: 2015-02-25, Last modification date: 2015-04-22) |
Primary citation | Peng, L.,Oganesyan, V.,Wu, H.,Dall'Acqua, W.F.,Damschroder, M.M. Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody. MAbs, 7:428-439, 2015 Cited by PubMed: 25606664DOI: 10.1080/19420862.2015.1007810 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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