4QXG

Antigen binding fragment of an anti IFNAR1 antibody

Summary for 4QXG

DescriptorFab, heavy chain, IgG1, Fab, light chain, IgG1, POTASSIUM ION, ... (6 entities in total)
Functional Keywordsigv and igc type folds, antigen binding, ifnar1, interferon alpha receptor 1, immune system
Biological sourceHomo sapiens
Total number of polymer chains2
Total molecular weight47243.67
Authors
Oganesyan, V.Y.,Dall'Acqua, W.F. (deposition date: 2014-07-20, release date: 2015-02-25, Last modification date: 2015-04-22)
Primary citation
Peng, L.,Oganesyan, V.,Wu, H.,Dall'Acqua, W.F.,Damschroder, M.M.
Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody.
MAbs, 7:428-439, 2015
PubMed: 25606664 (PDB entries with the same primary citation)
DOI: 10.1080/19420862.2015.1007810
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22530.2%0.8%10.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload