3FJT

Crystal structure of a human Fc fragment engineered for extended serum half-life

Summary for 3FJT

Entry DOI	10.2210/pdb3fjt/pdb
Descriptor	Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	fc, igg1, fcrn binding, ch3-ch3 association, glycoprotein, immunoglobulin c region, immunoglobulin domain, secreted, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted : P01857
Total number of polymer chains	2
Total formula weight	50458.17
Authors	Oganesyan, V.,Wu, H.,Dall'Acqua, W.F. (deposition date: 2008-12-15, release date: 2009-03-24, Last modification date: 2021-10-20)
Primary citation	Oganesyan, V.,Damschroder, M.M.,Woods, R.M.,Cook, K.E.,Wu, H.,Dall'acqua, W.F. Structural characterization of a human Fc fragment engineered for extended serum half-life. Mol.Immunol., 46:1750-1755, 2009 Cited by PubMed: 19250681 DOI: 10.1016/j.molimm.2009.01.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation