3FJT
Crystal structure of a human Fc fragment engineered for extended serum half-life
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-1 chain C region | polymer | 209 | 23765.7 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A, B: 236 - 444 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Tyr 252 | Met 135 | engineered mutation |
| Thr 254 | Ser 137 | engineered mutation |
| Glu 256 | Thr 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47531.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2926.7 | |
| All* | Total formula weight | 50458.2 |
