6TCI
 
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1U36
 | | Crystal structure of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-21 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3Y
 | | Crystal structure of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-22 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U42
 | | Crystal structure of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-23 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U41
 | | Crystal structure of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-23 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3Z
 | | Crystal structure of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-23 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1U3J
 | | Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-22 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
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1NK1
 | | NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION | | 分子名称: | PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR) | | 著者 | Chirgadze, D.Y, Hepple, J.P, Zhou, H, Byrd, R.A, Blundell, T.L, Gherardi, E. | | 登録日 | 1998-08-20 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nat.Struct.Biol., 6, 1999
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5JIP
 | | Crystal structure of the Clostridium perfringens spore cortex lytic enzyme SleM | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cortical-lytic enzyme, MAGNESIUM ION | | 著者 | Chirgadze, D.Y, Christie, G, Ustok, F.I, Al-Riyami, B, Stott, K. | | 登録日 | 2016-04-22 | | 公開日 | 2016-08-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination.
Proteins, 84, 2016
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3KX8
 | | Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK | | 分子名称: | fluoroacetyl-CoA thioesterase | | 著者 | Chirgadze, D.Y, Dias, M.V.B, Huang, F, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L. | | 登録日 | 2009-12-02 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J.Biol.Chem., 285, 2010
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2QM4
 | | Crystal structure of human XLF/Cernunnos, a non-homologous end-joining factor | | 分子名称: | Non-homologous end-joining factor 1 | | 著者 | Li, Y, Chirgadze, D.Y, Sibanda, B.L, Bolanos-Garcia, V.M, Davies, O.R, Blundell, T.L. | | 登録日 | 2007-07-14 | | 公開日 | 2007-12-11 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.
Embo J., 27, 2008
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5BOI
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7NFC
 | | Cryo-EM structure of NHEJ super-complex (dimer) | | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2021-02-05 | | 公開日 | 2021-08-18 | | 最終更新日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
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7NFE
 | | Cryo-EM structure of NHEJ super-complex (monomer) | | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2021-02-06 | | 公開日 | 2021-08-18 | | 最終更新日 | 2021-09-22 | | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
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2FN0
 | | Crystal structure of Yersinia enterocolitica salicylate synthase (Irp9) | | 分子名称: | ACETATE ION, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Kerbarh, O, Chirgadze, D.Y, Blundell, T.L, Abell, C. | | 登録日 | 2006-01-10 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate.
J.Mol.Biol., 357, 2006
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2FN1
 | | Crystal structures of Yersinia enterocolitica salicylate synthase (Irp9) in complex with the reaction products salicylate and pyruvate | | 分子名称: | 2-HYDROXYBENZOIC ACID, MAGNESIUM ION, PYRUVIC ACID, ... | | 著者 | Kerbarh, O, Chirgadze, D.Y, Blundell, T.L, Abell, C. | | 登録日 | 2006-01-10 | | 公開日 | 2006-02-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate.
J.Mol.Biol., 357, 2006
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3W03
 | | XLF-XRCC4 complex | | 分子名称: | DNA repair protein XRCC4, Non-homologous end-joining factor 1 | | 著者 | Wu, Q, Ochi, T, Matak-Vinkovic, D, Robinson, C.V, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2012-10-17 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (8.492 Å) | | 主引用文献 | Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions
Biochem.Soc.Trans., 39, 2011
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3V42
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3VNN
 | | Crystal Structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA ligase IV | | 分子名称: | DNA ligase 4 | | 著者 | Ochi, T, Wu, Q, Chirgadze, D.Y, Grossmann, J.G, Bolanos-Garcia, V.M, Blundell, T.L. | | 登録日 | 2012-01-17 | | 公開日 | 2012-06-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | | 主引用文献 | Structural insights into the role of domain flexibility in human DNA ligase IV
Structure, 20, 2012
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5M2K
 | | Crystal structure of vancomycin-Zn(II) complex | | 分子名称: | 1,2-ETHANEDIOL, ZINC ION, vancomycin, ... | | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | | 登録日 | 2016-10-13 | | 公開日 | 2017-07-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria.
Sci Rep, 7, 2017
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3G04
 | | Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, ... | | 著者 | Sanders, J, Chirgadze, D.Y, Sanders, P, Baker, S, Sullivan, A, Bhardwaja, A, Bolton, J, Reeve, M, Nakatake, N, Evans, M, Richards, T, Powell, M, Miguel, R.N, Blundell, T.L, Furmaniak, J, Smith, B.R. | | 登録日 | 2009-01-27 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
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5M2H
 | | Crystal structure of vancomycin-Zn(II)-citrate complex | | 分子名称: | CITRIC ACID, HEXAETHYLENE GLYCOL, Vancomycin, ... | | 著者 | Zarkan, A, Macklyne, H.-R, Chirgadze, D.Y, Bond, A.D, Hesketh, A.R, Hong, H.-J. | | 登録日 | 2016-10-13 | | 公開日 | 2017-07-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria.
Sci Rep, 7, 2017
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5LSP
 | | 107_A07 Fab in complex with fragment of the Met receptor | | 分子名称: | 107_A07 Fab heavy chain, 107_A07 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | DiCara, D, Chirgadze, D.Y, Pope, A, Karatt-Vellatt, A, Winter, A, van den Heuvel, J, Gherardi, E, McCafferty, J. | | 登録日 | 2016-09-05 | | 公開日 | 2017-09-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.605 Å) | | 主引用文献 | Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
Sci Rep, 7, 2017
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5LUQ
 | | Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) | | 分子名称: | C-terminal fragment of KU80 (KU80ct194), DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit | | 著者 | Sibanda, B.L, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L. | | 登録日 | 2016-09-09 | | 公開日 | 2017-02-15 | | 最終更新日 | 2018-03-28 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Science, 355, 2017
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6ZFP
 | | Cryo-EM structure of DNA-PKcs (State 2) | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-17 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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