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6HN4
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BU of 6hn4 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4
著者Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
登録日2018-09-14
公開日2018-11-21
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
6HN5
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BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
著者Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
登録日2018-09-14
公開日2018-11-21
最終更新日2022-03-30
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
2ETL
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BU of 2etl by Molmil
Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1)
分子名称: CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L1
著者Das, C, Hoang, Q.Q, Kreinbring, C.A, Luchansky, S.J, Meray, R.K, Ray, S.S, Lansbury, P.T, Ringe, D, Petsko, G.A.
登録日2005-10-27
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Proc.Natl.Acad.Sci.USA, 103, 2006
3VOP
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BU of 3vop by Molmil
Structure of Vaccinia virus A27
分子名称: DI(HYDROXYETHYL)ETHER, Protein A27
著者Chang, T.H, Ko, T.P, Hsieh, F.L, Wang, A.H.J.
登録日2012-01-31
公開日2013-03-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein.
Plos Pathog., 9, 2013
5KQV
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BU of 5kqv by Molmil
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ...
著者Lawrence, M.C, Smith, B.J, Croll, T.I.
登録日2016-07-06
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
2JUU
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BU of 2juu by Molmil
allo-ThrA3 DKP-insulin
分子名称: Insulin A chain, Insulin B chain
著者Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
登録日2007-09-03
公開日2007-10-16
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUM
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BU of 2jum by Molmil
ThrA3-DKP-insulin
分子名称: Insulin A chain, Insulin B chain
著者Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
登録日2007-08-31
公開日2007-10-16
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUV
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BU of 2juv by Molmil
AbaA3-DKP-insulin
分子名称: Insulin A chain, Insulin B chain
著者Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A.
登録日2007-09-05
公開日2007-10-16
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2MLI
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BU of 2mli by Molmil
NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin
分子名称: Insulin
著者Yang, Y, Weiss, M.
登録日2014-02-27
公開日2014-08-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
3W11
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BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
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BU of 3w13 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J, Brzozowski, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (4.303 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
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BU of 3w12 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Smith, B.J, Brzozowsk, A.M.
登録日2012-11-06
公開日2013-01-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (4.301 Å)
主引用文献How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
2MPI
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BU of 2mpi by Molmil
Solution structure of B24G insulin
分子名称: insulin chain A, insulin chain B
著者Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A.
登録日2014-05-19
公開日2014-12-24
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
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BU of 4nib by Molmil
Crystal structure of human insulin mutant B20 D-ala, B23 D-ala
分子名称: Insulin A chain, Insulin B chain
著者Menting, J.G, Lawrence, M.C.
登録日2013-11-05
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
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BU of 4oga by Molmil
Insulin in complex with Site 1 of the human insulin receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
著者Lawrence, M.C, Menting, J.G.
登録日2014-01-15
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4R8W
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BU of 4r8w by Molmil
Crystal structure of H7 hemagglutinin from A/Anhui/1/2013 in complex with a neutralizing antibody CT149
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of neutralizing antibody CT149, Hemagglutinin, ...
著者Wu, Y, Shi, Y, Qi, J, Gao, G.F.
登録日2014-09-03
公開日2015-08-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.795 Å)
主引用文献A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
Nat Commun, 6, 2015
4UBD
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BU of 4ubd by Molmil
Crystal structure of a neutralizing human monoclonal antibody with 1968 H3 HA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Shore, D.A, Yang, H, Cho, M, Donis, R.O, Stevens, J.
登録日2014-08-12
公開日2015-06-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus.
Nat Commun, 6, 2015
2OPP
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BU of 2opp by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
分子名称: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Chan, S.J.H, Kleim, J, Stammers, D.K.
登録日2007-01-30
公開日2007-05-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007

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