4V8A
 
 | | The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D, Johnson, F.A, Steitz, T.A. | | 登録日 | 2011-12-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
J.Mol.Biol., 416, 2012
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4W2H
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. | | 登録日 | 2014-09-12 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
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5VKQ
 | | Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, No mechanoreceptor potential C isoform L | | 著者 | Jin, P, Bulkley, D, Guo, Y, Zhang, W, Guo, Z, Huynh, W, Wu, S, Meltzer, S, Chen, T, Jan, L.Y, Jan, Y.-N, Cheng, Y. | | 登録日 | 2017-04-22 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Nature, 547, 2017
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4PLX
 | | Crystal structure of the triple-helical stability element at the 3' end of MALAT1 | | 分子名称: | Core ENE hairpin and A-rich tract from MALAT1 | | 著者 | Brown, J.A, Bulkley, D, Wang, J, Valenstein, M.L, Yario, T.A, Steitz, T.A, Steitz, J.A. | | 登録日 | 2014-05-19 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix.
Nat.Struct.Mol.Biol., 21, 2014
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7KKJ
 | | Structure of anti-SARS-CoV-2 Spike nanobody mNb6 | | 分子名称: | CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6 | | 著者 | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
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5T4D
 | | Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2 | | 著者 | Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E. | | 登録日 | 2016-08-29 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell, 167, 2016
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6BGJ
 | | Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG | | 分子名称: | Anoctamin-1, CALCIUM ION | | 著者 | Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, L, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y. | | 登録日 | 2017-10-28 | | 公開日 | 2017-12-27 | | 最終更新日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
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6BGI
 | | Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc | | 分子名称: | Anoctamin-1, CALCIUM ION | | 著者 | Dang, S, Feng, S, Tien, J, Peters, C.J, Bulkley, D, Lolicato, M, Zhao, J, Zuberbuhler, K, Ye, W, Qi, J, Chen, T, Craik, C.S, Jan, Y.N, Minor Jr, D.L, Cheng, Y, Jan, L.Y. | | 登録日 | 2017-10-28 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
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4W2F
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. | | 登録日 | 2014-09-12 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
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4W2G
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. | | 登録日 | 2014-09-12 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
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7KKK
 | | SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
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7KKL
 | | SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
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4V7Z
 | | Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | | 登録日 | 2010-08-18 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4V7W
 | | Structure of the Thermus thermophilus ribosome complexed with chloramphenicol. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | | 登録日 | 2010-08-16 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4V9R
 | | Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
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4V7Y
 | | Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | | 登録日 | 2010-08-18 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4V7X
 | | Structure of the Thermus thermophilus ribosome complexed with erythromycin. | | 分子名称: | 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A. | | 登録日 | 2010-08-17 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4V9S
 | | Crystal structure of antibiotic GE82832 bound to 70S ribosome | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-09 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
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6MG8
 | | Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched | | 分子名称: | CHOLESTEROL, Protein patched homolog 1 | | 著者 | Zhang, Y, Bulkley, D, Xin, Y, Roberts, K.J, Asarnow, D.E, Sharma, A, Myers, B.R, Cho, W, Cheng, Y, Beachy, P.A. | | 登録日 | 2018-09-13 | | 公開日 | 2018-11-28 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
Cell, 175, 2018
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4V95
 | | Crystal structure of YAEJ bound to the 70S ribosome | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | | 著者 | Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A. | | 登録日 | 2012-01-27 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome.
Science, 335, 2012
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4W2E
 | | Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Gagnon, M.G, Lin, J, Steitz, T.A. | | 登録日 | 2014-06-04 | | 公開日 | 2014-10-01 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome.
Science, 345, 2014
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8VSU
 | | Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Calcium-binding protein 39, Isoform 3 of STE20-related kinase adapter protein alpha, ... | | 著者 | Chan, L.M, Courteau, B.J, Verba, K.A. | | 登録日 | 2024-01-24 | | 公開日 | 2024-07-10 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
J.Struct.Biol., 216, 2024
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8SBE
 | | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | | 分子名称: | Vesicular glutamate transporter 2 | | 著者 | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | | 登録日 | 2023-04-03 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
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4WQY
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid) | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Lin, J, Gagnon, M.G, Steitz, T.A. | | 登録日 | 2014-10-22 | | 公開日 | 2015-01-28 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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6D1W
 | | human PKD2 F604P mutant | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | | 著者 | Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E. | | 登録日 | 2018-04-12 | | 公開日 | 2018-06-27 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
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