4V9R

Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome

This is a large structure.

Summary for 4V9R

Integrates4NVU 4NVV 4NVW 4NVX
Related PRD IDPRD_001218
Descriptor16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... (61 entities in total)
Functional Keywords70s, ribosome, dityromycin, ge82832, ribosomal protein s12, ef-g, translocation, dityromycin and ge82832 bind protein s12 and block ef-g catalyzed translocation, 30s subunit with bound mrna, p-site trna, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceThermus thermophilus
More
Total number of polymer chains110
Total molecular weight4455124.47
Authors
Bulkley, D.P.,Brandi, L.,Polikanov, Y.S.,Fabbretti, A.,O'Connor, M.,Gualerzi, C.O.,Steitz, T.A. (deposition date: 2013-12-05, release date: 2014-07-09, Last modification date: 2014-12-10)
Primary citation
Bulkley, D.,Brandi, L.,Polikanov, Y.S.,Fabbretti, A.,O'Connor, M.,Gualerzi, C.O.,Steitz, T.A.
The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6:357-365, 2014
PubMed: 24412368 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2013.12.024
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.259150.9%11.9%1.9%0.45MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4v9r
no rotation
Molmil generated image of 4v9r
rotated about x axis by 90°
Molmil generated image of 4v9r
rotated about y axis by 90°
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