2G2U
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![BU of 2g2u by Molmil](/molmil-images/mine/2g2u) | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | 分子名称: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | 著者 | Reynolds, K.A, Thomson, J.M, Corbett, K.D, Bethel, C.R, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. | 登録日 | 2006-02-16 | 公開日 | 2006-07-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface. J.Biol.Chem., 281, 2006
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2G2W
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![BU of 2g2w by Molmil](/molmil-images/mine/2g2w) | Crystal Structure of the SHV D104K Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) complex | 分子名称: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein | 著者 | Reynolds, K.A, Thomson, J.M, Corbett, K.D, Bethel, C.R, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. | 登録日 | 2006-02-16 | 公開日 | 2006-07-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and Computational Characterization of the SHV-1 beta-Lactamase-beta-Lactamase Inhibitor Protein Interface. J.Biol.Chem., 281, 2006
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1TDL
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![BU of 1tdl by Molmil](/molmil-images/mine/1tdl) | Structure of Ser130Gly SHV-1 beta-lactamase | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Sun, T, Bethel, C.R, Bonomo, R.A, Knox, J.R. | 登録日 | 2004-05-23 | 公開日 | 2004-11-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant Biochemistry, 43, 2004
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1TDG
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![BU of 1tdg by Molmil](/molmil-images/mine/1tdg) | Complex of S130G SHV-1 beta-lactamase with tazobactam | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase SHV-1, ... | 著者 | Sun, T, Bethel, C.R, Bonomo, R.A, Knox, J.R. | 登録日 | 2004-05-21 | 公開日 | 2004-11-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant Biochemistry, 43, 2004
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3D4F
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![BU of 3d4f by Molmil](/molmil-images/mine/3d4f) | SHV-1 beta-lactamase complex with LN1-255 | 分子名称: | (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Pattanaik, P, Bethel, C.R, Hujer, A.M, Bonomo, R.A, Buynak, J.D, van den Akker, F. | 登録日 | 2008-05-14 | 公開日 | 2009-02-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem., 284, 2009
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3FV7
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![BU of 3fv7 by Molmil](/molmil-images/mine/3fv7) | OXA-24 beta-lactamase complex with SA4-44 inhibitor | 分子名称: | (2S)-2-[[2-methanoyl-7-(methoxycarbonylamino)indolizin-3-yl]amino]-3-methyl-3-sulfino-butanoic acid, Beta-lactamase OXA-24 | 著者 | Bou, G, Santillana, E, Sheri, A, Beceiro, A, Sampson, J.M, Kalp, M, Bethel, C.R, Distler, A.M, Drawz, S.M, Pagadala, S.R, Van den Akker, F, Bonomo, R.A, Romero, A, Buynak, J.D. | 登録日 | 2009-01-15 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. J.Am.Chem.Soc., 132, 2010
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2OV5
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![BU of 2ov5 by Molmil](/molmil-images/mine/2ov5) | Crystal structure of the KPC-2 carbapenemase | 分子名称: | BICINE, Carbapenemase | 著者 | Ke, W, Bethel, C.R, Thomson, J.M, Bonomo, R.A, van den Akker, F. | 登録日 | 2007-02-13 | 公開日 | 2007-05-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A beta-Lactamases. Biochemistry, 46, 2007
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7BDS
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![BU of 7bds by Molmil](/molmil-images/mine/7bds) | |
7BDR
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![BU of 7bdr by Molmil](/molmil-images/mine/7bdr) | Structure of CTX-M-15 E166Q mutant crystallised in the presence of tazobactam (AAI101) | 分子名称: | Beta-lactamase, CHLORIDE ION, SODIUM ION, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2020-12-22 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (0.91 Å) | 主引用文献 | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 13, 2022
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4X6T
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![BU of 4x6t by Molmil](/molmil-images/mine/4x6t) | M.tuberculosis betalactamase complexed with inhibitor EC19 | 分子名称: | 3-[(2R)-2-(dihydroxyboranyl)-2-{[(2R)-2-{[(4-ethyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}ethyl]benzoic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Hazra, S. | 登録日 | 2014-12-09 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Inhibiting the beta-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs). ACS Infect Dis, 1, 2015
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4FCF
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![BU of 4fcf by Molmil](/molmil-images/mine/4fcf) | K234R: apo structure of inhibitor resistant beta-lactamase | 分子名称: | 2-AMINOETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Rodkey, E.A, van den Akker, F. | 登録日 | 2012-05-24 | 公開日 | 2012-12-26 | 最終更新日 | 2013-10-02 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase. J.Med.Chem., 56, 2013
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4FH4
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![BU of 4fh4 by Molmil](/molmil-images/mine/4fh4) | |
4FD8
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![BU of 4fd8 by Molmil](/molmil-images/mine/4fd8) | Structure of apo S70C SHV beta-lactamase | 分子名称: | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Rodkey, E.A, van den Akker, F. | 登録日 | 2012-05-26 | 公開日 | 2012-09-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase J.Am.Chem.Soc., 134, 2012
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7UTB
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![BU of 7utb by Molmil](/molmil-images/mine/7utb) | KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076 | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron | 著者 | van den Akker, F, Alsenani, T.A. | 登録日 | 2022-04-26 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses. Antimicrob.Agents Chemother., 67, 2023
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6MPQ
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![BU of 6mpq by Molmil](/molmil-images/mine/6mpq) | 1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514 | 分子名称: | (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, Beta-lactamase, CHLORIDE ION | 著者 | van den Akker, F, Kumar, V. | 登録日 | 2018-10-08 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. MBio, 10, 2019
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5WIH
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![BU of 5wih by Molmil](/molmil-images/mine/5wih) | |
5WIG
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![BU of 5wig by Molmil](/molmil-images/mine/5wig) | |
2ZD8
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![BU of 2zd8 by Molmil](/molmil-images/mine/2zd8) | SHV-1 class A beta-lactamase complexed with meropenem | 分子名称: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Nukaga, M, Knox, J.R, Hujer, A, Bonomo, R.A. | 登録日 | 2007-11-20 | 公開日 | 2008-09-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1. J.Am.Chem.Soc., 130, 2008
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6Z7J
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![BU of 6z7j by Molmil](/molmil-images/mine/6z7j) | |
6Z7H
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![BU of 6z7h by Molmil](/molmil-images/mine/6z7h) | |
6Z7I
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![BU of 6z7i by Molmil](/molmil-images/mine/6z7i) | |
6Z7K
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![BU of 6z7k by Molmil](/molmil-images/mine/6z7k) | Crystal structure of CTX-M-15 in complex with the imine form of hydrolysed tazobactam | 分子名称: | (2~{S},3~{S})-3-[bis(oxidanylidene)-$l^{5}-sulfanyl]-3-methyl-2-[(~{E})-3-oxidanylidenepropylideneamino]-4-(1,2,3-triaz ol-1-yl)butanoic acid, Beta-lactamase, CHLORIDE ION, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2020-05-31 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 2022
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7QQC
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![BU of 7qqc by Molmil](/molmil-images/mine/7qqc) | Structure of CTX-M-15 K73A mutant | 分子名称: | Beta-lactamase, CHLORIDE ION, SULFATE ION | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2022-01-07 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 13, 2022
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7QQ5
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![BU of 7qq5 by Molmil](/molmil-images/mine/7qq5) | |
6OP6
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![BU of 6op6 by Molmil](/molmil-images/mine/6op6) | Structure of VIM-20 in the reduced state | 分子名称: | Metallo-beta-lactamase VIM-20, SODIUM ION, ZINC ION | 著者 | Page, R.C, Shurina, B.A, Montgomery, J.S, Orischak, M.G, Nix, J.C. | 登録日 | 2019-04-24 | 公開日 | 2019-10-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions. Mbio, 10, 2019
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