7QQ5

Structure of CTX-M-15 K73A mutant crystallised in the presence of enmetazobactam (AAI101)

Summary for 7QQ5

Entry DOI	10.2210/pdb7qq5/pdb
Descriptor	Beta-lactamase, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	beta-lactamase, inhibitor, antibiotic resistance, cross-link, antimicrobial protein
Biological source	Klebsiella pneumoniae IS53
Total number of polymer chains	1
Total formula weight	28654.59
Authors	Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2022-01-06, release date: 2022-05-25, Last modification date: 2024-01-31)
Primary citation	Hinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J. Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition. Mbio, 13:e0179321-e0179321, 2022 Cited by PubMed: 35612361 DOI: 10.1128/mbio.01793-21 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.95 Å)

Structure validation