3D4F

SHV-1 beta-lactamase complex with LN1-255

Summary for 3D4F

• Entry DOI: 10.2210/pdb3d4f/pdb
• Related: 1GA0 1SHV
• Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, ... (4 entities in total)
• Functional Keywords: beta-lactamase inhibitor, drug design, antibiotic resistance, hydrolase, plasmid
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 32767.67

Authors

Pattanaik, P.,Bethel, C.R.,Hujer, A.M.,Bonomo, R.A.,Buynak, J.D.,van den Akker, F. (deposition date: 2008-05-14, release date: 2009-02-10, Last modification date: 2024-04-03)

• Primary citation: Pattanaik, P.,Bethel, C.R.,Hujer, A.M.,Hujer, K.M.,Distler, A.M.,Taracila, M.,Anderson, V.E.,Fritsche, T.R.,Jones, R.N.,Pagadala, S.R.,van den Akker, F.,Buynak, J.D.,Bonomo, R.A.; Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE; J.Biol.Chem., 284:945-953, 2009; PubMed: 18955486; DOI: 10.1074/jbc.M806833200

Experimental method

X-RAY DIFFRACTION (1.55 Å)