3D4F
SHV-1 beta-lactamase complex with LN1-255
Summary for 3D4F
Entry DOI | 10.2210/pdb3d4f/pdb |
Related | 1GA0 1SHV |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, ... (4 entities in total) |
Functional Keywords | beta-lactamase inhibitor, drug design, antibiotic resistance, hydrolase, plasmid |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 32767.67 |
Authors | Pattanaik, P.,Bethel, C.R.,Hujer, A.M.,Bonomo, R.A.,Buynak, J.D.,van den Akker, F. (deposition date: 2008-05-14, release date: 2009-02-10, Last modification date: 2024-04-03) |
Primary citation | Pattanaik, P.,Bethel, C.R.,Hujer, A.M.,Hujer, K.M.,Distler, A.M.,Taracila, M.,Anderson, V.E.,Fritsche, T.R.,Jones, R.N.,Pagadala, S.R.,van den Akker, F.,Buynak, J.D.,Bonomo, R.A. Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem., 284:945-953, 2009 Cited by PubMed: 18955486DOI: 10.1074/jbc.M806833200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report