7QQC

Structure of CTX-M-15 K73A mutant

Summary for 7QQC

• Entry DOI: 10.2210/pdb7qqc/pdb
• Descriptor: Beta-lactamase, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: beta-lactamase, mutant, antibiotic resistance, antimicrobial protein
• Biological source: Klebsiella pneumoniae IS53
• Total number of polymer chains: 1
• Total formula weight: 28654.59

Authors

Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2022-01-07, release date: 2022-05-25, Last modification date: 2024-01-31)

• Primary citation: Hinchliffe, P.,Tooke, C.L.,Bethel, C.R.,Wang, B.,Arthur, C.,Heesom, K.J.,Shapiro, S.,Schlatzer, D.M.,Papp-Wallace, K.M.,Bonomo, R.A.,Spencer, J.; Penicillanic Acid Sulfones Inactivate the Extended-Spectrum beta-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of beta-Lactamase Inhibition.; Mbio, 13:e0179321-e0179321, 2022; PubMed: 35612361; DOI: 10.1128/mbio.01793-21

Experimental method

X-RAY DIFFRACTION (0.95 Å)