6MPQ
1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514
Summary for 6MPQ
Entry DOI | 10.2210/pdb6mpq/pdb |
Descriptor | Beta-lactamase, (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | beta-lactamase, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 1 |
Total formula weight | 28048.56 |
Authors | van den Akker, F.,Kumar, V. (deposition date: 2018-10-08, release date: 2019-02-27, Last modification date: 2023-11-15) |
Primary citation | Barnes, M.D.,Kumar, V.,Bethel, C.R.,Moussa, S.H.,O'Donnell, J.,Rutter, J.D.,Good, C.E.,Hujer, K.M.,Hujer, A.M.,Marshall, S.H.,Kreiswirth, B.N.,Richter, S.S.,Rather, P.N.,Jacobs, M.R.,Papp-Wallace, K.M.,van den Akker, F.,Bonomo, R.A. Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. MBio, 10:-, 2019 Cited by PubMed: 30862744DOI: 10.1128/mBio.00159-19 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report