6MPQ

1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514

Summary for 6MPQ

Entry DOI	10.2210/pdb6mpq/pdb
Descriptor	Beta-lactamase, (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	beta-lactamase, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Acinetobacter baumannii
Total number of polymer chains	1
Total formula weight	28048.56
Authors	van den Akker, F.,Kumar, V. (deposition date: 2018-10-08, release date: 2019-02-27, Last modification date: 2023-11-15)
Primary citation	Barnes, M.D.,Kumar, V.,Bethel, C.R.,Moussa, S.H.,O'Donnell, J.,Rutter, J.D.,Good, C.E.,Hujer, K.M.,Hujer, A.M.,Marshall, S.H.,Kreiswirth, B.N.,Richter, S.S.,Rather, P.N.,Jacobs, M.R.,Papp-Wallace, K.M.,van den Akker, F.,Bonomo, R.A. Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. MBio, 10:-, 2019 Cited by PubMed: 30862744 DOI: 10.1128/mBio.00159-19 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation