4FCF

K234R: apo structure of inhibitor resistant beta-lactamase

Summary for 4FCF

Entry DOI	10.2210/pdb4fcf/pdb
Descriptor	Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, 2-AMINOETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	class a beta-lactamse, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30077.38
Authors	Rodkey, E.A.,van den Akker, F. (deposition date: 2012-05-24, release date: 2012-12-26, Last modification date: 2013-10-02)
Primary citation	Winkler, M.L.,Rodkey, E.A.,Taracila, M.A.,Drawz, S.M.,Bethel, C.R.,Papp-Wallace, K.M.,Smith, K.M.,Xu, Y.,Dwulit-Smith, J.R.,Romagnoli, C.,Caselli, E.,Prati, F.,van den Akker, F.,Bonomo, R.A. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase. J.Med.Chem., 56:1084-1097, 2013 Cited by PubMed: 23252553 DOI: 10.1021/jm301490d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.09 Å)

Structure validation