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8J5R
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BU of 8j5r by Molmil
Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the resting state
分子名称: IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, Putative peptide transport permease protein Rv1283c, ...
著者Yang, X, Hu, T, Zhang, B, Rao, Z.
登録日2023-04-24
公開日2024-04-03
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.
Nat.Struct.Mol.Biol., 31, 2024
8J5T
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BU of 8j5t by Molmil
Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the catalytic intermediate state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ...
著者Yang, X, Hu, T, Zhang, B, Rao, Z.
登録日2023-04-24
公開日2024-04-03
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.
Nat.Struct.Mol.Biol., 31, 2024
8J5Q
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BU of 8j5q by Molmil
Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-translocation state
分子名称: Endogenous oligopeptide, IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, ...
著者Yang, X, Hu, T, Zhang, B, Rao, Z.
登録日2023-04-24
公開日2024-04-03
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.
Nat.Struct.Mol.Biol., 31, 2024
5YJG
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BU of 5yjg by Molmil
Structural insights into periostin functions
分子名称: CALCIUM ION, CHLORIDE ION, CYSTEINE, ...
著者Liu, H, Liu, J, Xu, F.
登録日2017-10-10
公開日2018-05-23
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.399 Å)
主引用文献Structural characterizations of human periostin dimerization and cysteinylation.
FEBS Lett., 592, 2018
9IKQ
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BU of 9ikq by Molmil
Crystal structure of OPTN LZD in complex with GTP-bound Rab8a(Q67L)
分子名称: 1,2-ETHANEDIOL, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Zhang, J, Pan, L.F.
登録日2024-06-28
公開日2024-12-25
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Molecular Basis of the Recognition of the Active Rab8a by Optineurin.
J.Mol.Biol., 436, 2024
5VIF
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BU of 5vif by Molmil
Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
分子名称: 2-{[(2E)-4-chlorobut-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose, CKII, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, ...
著者Jiang, J, Li, B, Hu, C.-W, Worth, M, Fan, D, Li, H.
登録日2017-04-15
公開日2017-10-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
Nat. Chem. Biol., 13, 2017
5VIE
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BU of 5vie by Molmil
Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase
分子名称: 2-{[(2E)-4-chlorobut-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose, 2-{[(2E)-but-2-enoyl]amino}-2-deoxy-beta-D-glucopyranose, CKII, ...
著者Jiang, J, Li, B, Hu, C.-W, Worth, M, Fan, D, Li, H.
登録日2017-04-15
公開日2017-10-18
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.
Nat. Chem. Biol., 13, 2017
5WAL
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BU of 5wal by Molmil
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称: N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
著者Ultsch, M.H, Magnuson, S.
登録日2017-06-26
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg. Med. Chem. Lett., 27, 2017
5WEV
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BU of 5wev by Molmil
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称: N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
著者Ultsch, M.H, Magnuson, S.
登録日2017-07-10
公開日2017-09-06
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg. Med. Chem. Lett., 27, 2017
3QWQ
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BU of 3qwq by Molmil
Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADNECTIN, ...
著者Sheriff, S.
登録日2011-02-28
公開日2012-02-01
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure, 20, 2012
5EJL
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BU of 5ejl by Molmil
MrkH, A novel c-di-GMP dependence transcription regulatory factor.
分子名称: 1,2-ETHANEDIOL, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Klebsiella pneumoniae genome assembly NOVST, ...
著者Wang, F, Zhu, D, Gu, L.
登録日2015-11-02
公開日2016-10-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The PilZ domain of MrkH represents a novel DNA binding motif
Protein Cell, 7, 2016
3QWR
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BU of 3qwr by Molmil
Crystal structure of IL-23 in complex with an adnectin
分子名称: ADNECTIN, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ...
著者Wei, A, Sheriff, S.
登録日2011-02-28
公開日2012-02-01
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure, 20, 2012
5WHG
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BU of 5whg by Molmil
Vms1 mitochondrial localization core
分子名称: Protein VMS1, ZINC ION
著者Fredrickson, E.K, Schubert, H.L, Rutter, J, Hill, C.P.
登録日2017-07-17
公開日2017-11-15
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.
Mol. Cell, 68, 2017
9JWG
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BU of 9jwg by Molmil
Cryo-EM Focused Refined Map of Human RNF213 E3 module and IpaH1.4 LRR domain
分子名称: E3 ubiquitin-protein ligase IpaH1.4, Ring finger protein 213
著者Zhang, H.
登録日2024-10-10
公開日2025-05-07
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity.
Nat Commun, 16, 2025
9JTA
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BU of 9jta by Molmil
Crystal structure of RNF213 RING domain bound to IpaH1.4 LRR domain
分子名称: E3 ubiquitin-protein ligase RNF213, RING-type E3 ubiquitin transferase, ZINC ION
著者Zhou, X.D, Wang, Y.R, Pan, L.F.
登録日2024-10-03
公開日2025-05-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity.
Nat Commun, 16, 2025
9JW1
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BU of 9jw1 by Molmil
Cryo-EM structure of Human RNF213
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ring finger protein 213
著者Zhang, H.
登録日2024-10-09
公開日2025-05-07
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity.
Nat Commun, 16, 2025
7V2Z
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BU of 7v2z by Molmil
ZIKV NS3helicase in complex with ssRNA and ATP-Mn2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Core protein, MANGANESE (II) ION, ...
著者Lin, M.M, Yang, H.T.
登録日2021-08-10
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.10101676 Å)
主引用文献Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.
Acs Infect Dis., 8, 2022
4H6H
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BU of 4h6h by Molmil
Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B(4-85)
分子名称: Fibrinogen-binding protein
著者Garcia, B.L, Geisbrecht, B.V.
登録日2012-09-19
公開日2012-12-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5024 Å)
主引用文献A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins.
J.Biol.Chem., 288, 2013
8STB
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BU of 8stb by Molmil
The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX
分子名称: GLYCEROL, Glyoxalase, SULFATE ION, ...
著者Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B.
登録日2023-05-09
公開日2024-05-22
最終更新日2025-06-04
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献An enzymatic dual-oxa Diels-Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (-)-anthrabenzoxocinone.
Nat.Chem., 2025
3BGL
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BU of 3bgl by Molmil
Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors
分子名称: (3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-4-(morpholin-4-ylsulfonyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
著者Finzel, B.C, Pavlovsky, A, Park, W.K.C.
登録日2007-11-26
公開日2008-01-29
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.225 Å)
主引用文献Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
8IS2
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BU of 8is2 by Molmil
Crystal structure of a polyketide aromatase/cyclase Abx(+)D from Actinomycetes sp. MA7150.
分子名称: Cyclase
著者Luo, S, Chen, X.
登録日2023-03-20
公開日2024-02-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin.
Proc.Natl.Acad.Sci.USA, 121, 2024
4H6I
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BU of 4h6i by Molmil
Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B
分子名称: Fibrinogen-binding protein
著者Garcia, B.L, Geisbrecht, B.V.
登録日2012-09-19
公開日2012-12-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.091 Å)
主引用文献A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins.
J.Biol.Chem., 288, 2013
6AZU
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BU of 6azu by Molmil
Holo IDO1 crystal structure
分子名称: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Lewis, H.A, Yan, C.
登録日2017-09-13
公開日2018-03-21
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AZV
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BU of 6azv by Molmil
IDO1/BMS-978587 crystal structure
分子名称: (1R,2S)-2-(4-[bis(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A.
登録日2017-09-13
公開日2018-03-21
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.755 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1SZJ
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BU of 1szj by Molmil
STRUCTURE OF HOLO-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE FROM PALINURUS VERSICOLOR REFINED 2.0 ANGSTROM RESOLUTION
分子名称: D-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
著者Song, S, Li, J, Lin, Z.
登録日1997-02-04
公開日1998-09-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Preliminary crystallographic studies of lobster D-glyceraldehyde-3-phosphate dehydrogenase and the modified enzyme carrying the fluorescent derivative.
J.Mol.Biol., 171, 1983

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