3BGL

Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Summary for 3BGL

Entry DOI	10.2210/pdb3bgl/pdb
Related	2Q1L 2Q6B 2Q6C 2R4F
Descriptor	3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-4-(morpholin-4-ylsulfonyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (3 entities in total)
Functional Keywords	oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin, alternative splicing, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	192272.95
Authors	Finzel, B.C.,Pavlovsky, A.,Park, W.K.C. (deposition date: 2007-11-26, release date: 2008-01-29, Last modification date: 2024-02-21)
Primary citation	Park, W.K.,Kennedy, R.M.,Larsen, S.D.,Miller, S.,Roth, B.D.,Song, Y.,Steinbaugh, B.A.,Sun, K.,Tait, B.D.,Kowala, M.C.,Trivedi, B.K.,Auerbach, B.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.H.,Robertson, A.,Sekerke, C. Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 18:1151-1156, 2008 Cited by PubMed: 18155906 DOI: 10.1016/j.bmcl.2007.11.124 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.225 Å)

Structure validation