2Q6B

Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors

Summary for 2Q6B

Entry DOI	10.2210/pdb2q6b/pdb
Related	2Q1L 2Q6C
Descriptor	3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, (3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	192392.89
Authors	Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (deposition date: 2007-06-04, release date: 2007-07-17, Last modification date: 2024-02-21)
Primary citation	Pfefferkorn, J.A.,Choi, C.,Song, Y.,Trivedi, B.K.,Larsen, S.D.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.,Robertson, A.,Sekerke, C.,Auerbach, B.,Pavlovsky, A.,Harris, M.S.,Bainbridge, G.,Caspers, N. Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17:4531-4537, 2007 Cited by PubMed: 17574411 DOI: 10.1016/j.bmcl.2007.05.097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation