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6AZU
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BU of 6azu by Molmil
Holo IDO1 crystal structure
分子名称: Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Lewis, H.A, Yan, C.
登録日2017-09-13
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7E0Z
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BU of 7e0z by Molmil
Crystal structure of PKAc-PLN complex
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLN, ...
著者Qin, J, Yuchi, Z.
登録日2021-01-28
公開日2022-04-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.162 Å)
主引用文献Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy.
Elife, 11, 2022
7F6L
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BU of 7f6l by Molmil
Crystal structure of human MUS81-EME2 complex
分子名称: Crossover junction endonuclease MUS81, Probable crossover junction endonuclease EME2
著者Hua, Z.K, Zhang, D.P, Yuan, C, Lin, Z.H.
登録日2021-06-25
公開日2022-03-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the human MUS81-EME2 complex.
Structure, 30, 2022
6AZV
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BU of 6azv by Molmil
IDO1/BMS-978587 crystal structure
分子名称: (1R,2S)-2-(4-[bis(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A.
登録日2017-09-13
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.755 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4RE1
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BU of 4re1 by Molmil
Crystal structure of human TEAD1 and disulfide-engineered YAP
分子名称: CHLORIDE ION, Transcriptional enhancer factor TEF-1, Yorkie homolog
著者Xu, Z, Zhou, Z.
登録日2014-09-21
公開日2014-11-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Faseb J., 29, 2015
6AZW
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BU of 6azw by Molmil
IDO1/FXB-001116 crystal structure
分子名称: (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A, Lammens, A, Steinbacher, S.
登録日2017-09-13
公開日2018-03-21
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3RT0
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BU of 3rt0 by Molmil
Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)
分子名称: Abscisic acid receptor PYL10, MAGNESIUM ION, Protein phosphatase 2C 16
著者Hao, Q, Yin, P, Li, W, Wang, L, Yan, C, Wang, J, Yan, N.
登録日2011-05-02
公開日2011-06-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.113 Å)
主引用文献The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins
Mol.Cell, 42, 2011
3RT2
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BU of 3rt2 by Molmil
Crystal structure of apo-PYL10
分子名称: Abscisic acid receptor PYL10
著者Hao, Q, Yin, P, Li, W, Wang, L, Yan, C, Wang, J, Yan, N.
登録日2011-05-02
公開日2011-06-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins
Mol.Cell, 42, 2011
4O9B
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BU of 4o9b by Molmil
The Structure of CC1-IH in human STIM1.
分子名称: CADMIUM ION, Stromal interaction molecule 1
著者Cui, B, Yang, X, Li, S, Shen, Y.
登録日2014-01-02
公開日2014-01-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.604 Å)
主引用文献The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1.
Plos One, 8, 2013
4RFM
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BU of 4rfm by Molmil
ITK kinase domain in complex with compound 1 N-{1-[(1,1-dioxo-1-thian-2-yl)(phenyl)methyl]-1H- pyrazol-4-yl}-5,5-difluoro-5a-methyl-1H,4H,4aH,5H,5aH,6H-cyclopropa[f]indazole-3-carboxamide
分子名称: (4aS,5aR)-N-{1-[(R)-[(2R)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl](phenyl)methyl]-1H-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK
著者McEwan, P.A, Barker, J.J, Eigenbrot, C.
登録日2014-09-26
公開日2015-04-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
J.Med.Chem., 58, 2015
7SSM
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BU of 7ssm by Molmil
Crystal structure of human STING R232 in complex with compound 11
分子名称: 2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid, Stimulator of interferon genes protein
著者Sack, J.S, Critton, D.A.
登録日2021-11-11
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
J.Med.Chem., 65, 2022
8T51
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BU of 8t51 by Molmil
Crystal structure of Fab 3.10C2 bound to TREM2
分子名称: 3.10C2 Fab heavy chain, 3.10C2 Fab light chain, ACETATE ION, ...
著者Hsu, P.L, Wallweber, H.
登録日2023-06-12
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
To Be Published
8T59
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BU of 8t59 by Molmil
Crystal structure of Para.09 bound to TREM2
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Para.09 heavy chain, ...
著者Wallweber, H, Hsu, P.L.
登録日2023-06-12
公開日2024-07-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
To Be Published
4R94
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BU of 4r94 by Molmil
Structure of the nickase domain of NS1 from MVM complexed with magnesium
分子名称: MAGNESIUM ION, Non-structural protein NS1
著者Liang, L, Zhao, H, Tang, L.
登録日2014-09-03
公開日2015-01-21
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.668 Å)
主引用文献Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
Virology, 476C, 2014
4PP4
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BU of 4pp4 by Molmil
Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication
分子名称: BETA-MERCAPTOETHANOL, Non-capsid protein NS-1, SODIUM ION
著者Tewary, S.K, Zhao, H, Tang, L.
登録日2014-02-26
公開日2015-01-21
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
Virology, 476C, 2014
1PSJ
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BU of 1psj by Molmil
ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS
分子名称: CALCIUM ION, PHOSPHOLIPASE A2
著者Wang, X.Q, Lin, Z.J.
登録日1995-05-24
公開日1996-07-11
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution.
J.Mol.Biol., 255, 1996
7WN7
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BU of 7wn7 by Molmil
Crystal structure of HearNPV P26
分子名称: CHLORIDE ION, SULFATE ION, p26
著者Kuang, W, Hu, Z, Gong, P.
登録日2022-01-17
公開日2022-11-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.
Nat Commun, 13, 2022
1B4W
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BU of 1b4w by Molmil
BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS-IMPLICATIONS FOR ITS ASSOCIATION AND ANTICOAGULANT ACTIVITIES BY X-RAY CRYSTALLOGRAPHY
分子名称: PROTEIN (PHOSPHOLIPASE A2), octyl beta-D-glucopyranoside
著者Zhao, K.H, Lin, Z.J.
登録日1998-12-30
公開日2000-01-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of basic phospholipase A2 from Agkistrodon halys Pallas: implications for its association, hemolytic and anticoagulant activities.
Toxicon, 38, 2000
2IE3
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BU of 2ie3 by Molmil
Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
分子名称: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2IE4
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BU of 2ie4 by Molmil
Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid
分子名称: MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ...
著者Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y.
登録日2006-09-17
公開日2006-11-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
Cell(Cambridge,Mass.), 127, 2006
2HV7
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BU of 2hv7 by Molmil
Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, J.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
7Y8T
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BU of 7y8t by Molmil
Structure of Cas7-11-crRNA in complex with TPR-CHAT
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (37-MER), ...
著者Wang, S, Guo, M, Zhu, Y, Huang, Z.
登録日2022-06-24
公開日2023-06-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT.
Cell Res., 32, 2022
7Y8Y
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BU of 7y8y by Molmil
Structure of Cas7-11-crRNA-tgRNA in complex with TPR-CHAT
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (37-MER), ...
著者Wang, S, Guo, M, Zhu, Y, Huang, Z.
登録日2022-06-24
公開日2023-06-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT.
Cell Res., 32, 2022
2HV6
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BU of 2hv6 by Molmil
Crystal structure of the phosphotyrosyl phosphatase activator
分子名称: MAGNESIUM ION, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, P.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
3WRS
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BU of 3wrs by Molmil
Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication
分子名称: COBALT (II) ION, Non-capsid protein NS-1
著者Tewary, S.K, Zhao, H, Tang, L.
登録日2014-02-27
公開日2015-01-21
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
Virology, 476C, 2014

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