8T59
Crystal structure of Para.09 bound to TREM2
Summary for 8T59
Entry DOI | 10.2210/pdb8t59/pdb |
Descriptor | Para.09 heavy chain, Para.09 light chain, Triggering receptor expressed on myeloid cells 2, ... (7 entities in total) |
Functional Keywords | antibody, fab, complex, antigen, peptide binding protein, immune system-peptide binding protein complex, immune system/peptide binding protein |
Biological source | synthetic construct More |
Total number of polymer chains | 6 |
Total formula weight | 101863.26 |
Authors | Wallweber, H.,Hsu, P.L. (deposition date: 2023-06-12, release date: 2024-07-31, Last modification date: 2024-10-09) |
Primary citation | Hsiao, Y.C.,Wallweber, H.A.,Alberstein, R.G.,Lin, Z.,Du, C.,Etxeberria, A.,Aung, T.,Shang, Y.,Seshasayee, D.,Seeger, F.,Watkins, A.M.,Hansen, D.V.,Bohlen, C.J.,Hsu, P.L.,Hotzel, I. Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining. Nat Commun, 15:8382-8382, 2024 Cited by PubMed: 39333507DOI: 10.1038/s41467-024-52442-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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