8T51

Crystal structure of Fab 3.10C2 bound to TREM2

Summary for 8T51

Entry DOI	10.2210/pdb8t51/pdb
Descriptor	3.10C2 Fab heavy chain, 3.10C2 Fab light chain, Triggering receptor expressed on myeloid cells 2 peptide, ... (9 entities in total)
Functional Keywords	antibody, fab, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	102728.02
Authors	Hsu, P.L.,Wallweber, H. (deposition date: 2023-06-12, release date: 2024-06-19)
Primary citation	Hsiao, Y.,Lin, Z.,Du, C.,Echeverria, A.,Wallweber, H.A.,Aung, T.,Alberstein, R.G.,Shang, Y.,Seeger, F.,Watkins, A.,Seshasayee, D.,Hansen, D.V.,Bolen, C.,Hsu, P.L.,Hotzel, I. Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining To Be Published,
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation