8T51
Crystal structure of Fab 3.10C2 bound to TREM2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | 3.10C2 Fab heavy chain | polymer | 222 | 23694.5 | 2 | Homo sapiens (human) | ||
| 2 | B, D (B, D) | 3.10C2 Fab light chain | polymer | 219 | 23974.9 | 2 | Homo sapiens (human) | ||
| 3 | E, F (E, F) | Triggering receptor expressed on myeloid cells 2 peptide | polymer | 20 | 2274.4 | 2 | UniProt (Q9NZC2) | Homo sapiens | TREM-2,Triggering receptor expressed on monocytes 2 |
| 4 | DA, EA, G, H, I... (D, A, B, C) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | J, KA, LA, M, MA... (A, E, F, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 6 | AA, BA, FA, GA, IA... (C, D, A, B) | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
| 7 | CA, HA, L, W, X (C, D, A, B) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 8 | JA, NA, T, U (E, F, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 9 | OA, PA, QA, RA, SA... (A, B, C, D, E...) | water | water | 18.0 | 532 | Chemie (HOH) |
Sequence modifications
E, F: 148 - 167 (UniProt: Q9NZC2)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 99887.7 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 2840.3 | |
| All* | Total formula weight | 102728.0 |
