4RE1

Crystal structure of human TEAD1 and disulfide-engineered YAP

Summary for 4RE1

• Entry DOI: 10.2210/pdb4re1/pdb
• Descriptor: Transcriptional enhancer factor TEF-1, Yorkie homolog, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: immunoglobulin-like fold, transcription regulation, dna-binding, protein-protein interaction, phosphoprotein, nucleus, transcription-protein binding complex, transcription/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P28347; Cytoplasm: P46937
• Total number of polymer chains: 4
• Total formula weight: 83009.26

Authors

Xu, Z.,Zhou, Z. (deposition date: 2014-09-21, release date: 2014-11-19, Last modification date: 2023-11-08)

• Primary citation: Zhou, Z.,Hu, T.,Xu, Z.,Lin, Z.,Zhang, Z.,Feng, T.,Zhu, L.,Rong, Y.,Shen, H.,Luk, J.M.,Zhang, X.,Qin, N.; Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.; Faseb J., 29:724-732, 2015; PubMed: 25384421; DOI: 10.1096/fj.14-262980

Experimental method

X-RAY DIFFRACTION (2.2 Å)