7SSM

Crystal structure of human STING R232 in complex with compound 11

Summary for 7SSM

Entry DOI	10.2210/pdb7ssm/pdb
Descriptor	Stimulator of interferon genes protein, 2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid (3 entities in total)
Functional Keywords	receptor, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	24390.25
Authors	Sack, J.S.,Critton, D.A. (deposition date: 2021-11-11, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Cherney, E.C.,Zhang, L.,Lo, J.,Huynh, T.,Wei, D.,Ahuja, V.,Quesnelle, C.,Schieven, G.L.,Futran, A.,Locke, G.A.,Lin, Z.,Monereau, L.,Chaudhry, C.,Blum, J.,Li, S.,Fereshteh, M.,Li-Wang, B.,Gangwar, S.,Pan, C.,Chong, C.,Zhu, X.,Posy, S.L.,Sack, J.S.,Zhang, P.,Ruzanov, M.,Harner, M.,Akhtar, F.,Schroeder, G.M.,Vite, G.,Fink, B. Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization. J.Med.Chem., 65:3518-3538, 2022 Cited by PubMed: 35108011 DOI: 10.1021/acs.jmedchem.1c01986 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation