7SSM

Crystal structure of human STING R232 in complex with compound 11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Stimulator of interferon genes protein	polymer	210	24053.9	1	UniProt (A0A2R3XZB7) Pfam (PF15009) UniProt (by SIFTS) (Q86WV6)	Homo sapiens (Human)	Transmembrane protein 173
2	B (A)	2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid	non-polymer		336.3	1	Chemie (B7L)
3	C (A)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

A: 155 - 341 (UniProt: A0A2R3XZB7)

PDB	External Database	Details
Met 132	-	expression tag
Gly 133	-	expression tag
Ser 134	-	expression tag
Ser 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
Gly 144	-	expression tag
Glu 145	-	expression tag
Thr 146	-	expression tag
Val 147	-	expression tag
Arg 148	-	expression tag
Phe 149	-	expression tag
Gln 150	-	expression tag
Gly 151	-	expression tag
His 152	-	expression tag
Met 153	-	expression tag
Ser 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	24053.9
Non-Polymers*	Number of molecules	1
	Total formula weight	336.3
All*	Total formula weight	24390.2

*Water molecules are not included.