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7WZR
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BU of 7wzr by Molmil
Cryo-EM structure of Mec1-HU
分子名称: DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1
著者Zhang, Q, Zhang, Q.
登録日2022-02-19
公開日2023-03-08
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins.
Cell Discov, 8, 2022
8H7B
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BU of 8h7b by Molmil
The crystal structure of human mcl1 kinase domain in complex with MCL1-M-EBA
分子名称: 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Zhu, C.J, Zhang, Z.M.
登録日2022-10-19
公開日2023-02-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.46408451 Å)
主引用文献2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
J.Am.Chem.Soc., 2023
8H7F
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BU of 8h7f by Molmil
The crystal structure of human abl1 kinase domain in complex with abl1-B-EBA
分子名称: 1-[6-(6-methoxyisoquinolin-7-yl)-1,3-benzothiazol-2-yl]-3-(2-oxidanylideneethyl)urea, Tyrosine-protein kinase ABL1
著者Zhu, C.J, Zhang, Z.M.
登録日2022-10-20
公開日2023-03-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.45013428 Å)
主引用文献2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
J.Am.Chem.Soc., 2023
8H7H
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BU of 8h7h by Molmil
The crystal structure of human abl1 kinase domain in complex with abl1-A-EBA
分子名称: 5-[3-(6-methoxyisoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-methyl-N-prop-2-ynyl-pyridine-3-carboxamide, Tyrosine-protein kinase ABL1
著者Zhu, C.J, Zhang, Z.M.
登録日2022-10-20
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.27789712 Å)
主引用文献2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases.
J.Am.Chem.Soc., 2023
8JMX
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BU of 8jmx by Molmil
The crystal structure of human aurka kinase domain in complex with AURKA-A2
分子名称: 5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-oxidanyl-benzaldehyde, Aurora kinase A
著者Zhu, C.J, Zhang, Z.M.
登録日2023-06-05
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.95020175 Å)
主引用文献Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently.
Chem.Commun.(Camb.), 59, 2023
8JF4
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BU of 8jf4 by Molmil
The crystal structure of human AURKA kinase domain in complex with AURKA-compound 9
分子名称: 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A
著者Zhu, C.J.
登録日2023-05-17
公開日2024-02-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.89288354 Å)
主引用文献Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.
Angew.Chem.Int.Ed.Engl., 63, 2024
8JF3
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BU of 8jf3 by Molmil
C-Src in complex with compound 9
分子名称: 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide, Proto-oncogene tyrosine-protein kinase Src
著者Zhang, Z.M, Huang, H.S.
登録日2023-05-17
公開日2024-02-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.84647632 Å)
主引用文献Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.
Angew.Chem.Int.Ed.Engl., 63, 2024
8J4A
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BU of 8j4a by Molmil
Crystal structure of OY phytoplasma SAP05 in complex with AtRPN10
分子名称: 26S proteasome non-ATPase regulatory subunit 4 homolog, Sequence-variable mosaic (SVM) signal sequence domain-containing protein
著者Dong, C, Yan, X, Yuan, X.
登録日2023-04-19
公開日2024-02-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors.
Nat Commun, 15, 2024
8J4B
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BU of 8j4b by Molmil
Crystal structure of OY phytoplasma SAP05 in complex with AtSPL13
分子名称: Sequence-variable mosaic (SVM) signal sequence domain-containing protein, Squamosa promoter-binding-like protein 13A, ZINC ION
著者Dong, C, Yan, X, Yuan, X.
登録日2023-04-19
公開日2024-02-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors.
Nat Commun, 15, 2024
8J49
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BU of 8j49 by Molmil
Crystal structure of OY phytoplasma SAP05 in complex with AtSPL5
分子名称: Sequence-variable mosaic (SVM) signal sequence domain-containing protein, Squamosa promoter-binding-like protein 5, ZINC ION
著者Dong, C, Yan, X, Yuan, X.
登録日2023-04-19
公開日2024-02-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors.
Nat Commun, 15, 2024
8J48
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BU of 8j48 by Molmil
Crystal structure of OY phytoplasma SAP05 in complex with AtGATA18
分子名称: GATA transcription factor 18, Sequence-variable mosaic (SVM) signal sequence domain-containing protein, ZINC ION
著者Dong, C, Yan, X, Yuan, X.
登録日2023-04-19
公開日2024-02-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Molecular basis of SAP05-mediated ubiquitin-independent proteasomal degradation of transcription factors.
Nat Commun, 15, 2024
8JG8
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BU of 8jg8 by Molmil
The crystal structure of human aurka kinase domain in the complex with aurka-compound 25
分子名称: 4-[5-[3-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine, Aurora kinase A
著者Zhu, C.J, Zhang, Z.M.
登録日2023-05-19
公開日2024-04-17
実験手法X-RAY DIFFRACTION (2.90002346 Å)
主引用文献Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development.
Angew.Chem.Int.Ed.Engl., 63, 2024
7E36
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BU of 7e36 by Molmil
A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family), ...
著者Zhang, B, Ge, H.M.
登録日2021-02-08
公開日2021-03-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis.
Nat Commun, 12, 2021
7EAK
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BU of 7eak by Molmil
Echovirus3 full particle in complex with 5G3 fab
分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ...
著者Feng, R.
登録日2021-03-07
公開日2021-07-14
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
7EAH
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BU of 7eah by Molmil
Echovirus3 empty expanded particle
分子名称: Capsid protein VP0, Capsid protein VP1, Capsid protein VP3
著者Feng, R.
登録日2021-03-07
公開日2021-07-14
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
7EAI
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BU of 7eai by Molmil
Echovirus3 empty compacted particle
分子名称: Capsid protein VP0, Capsid protein VP1, Capsid protein VP3, ...
著者Feng, R.
登録日2021-03-07
公開日2021-07-14
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
7EAJ
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BU of 7eaj by Molmil
Echovirus3 empty expanded particle in complex with 5G3 fab
分子名称: VP0, VP1, VP3, ...
著者Feng, R.
登録日2021-03-07
公開日2021-07-14
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.
Cell Discov, 7, 2021
7U6R
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BU of 7u6r by Molmil
Cryo-EM structure of PDF-2180 Spike glycoprotein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PDF-2180 Spike glycoprotein
著者Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-03-05
公開日2022-11-30
最終更新日2023-01-04
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Close relatives of MERS-CoV in bats use ACE2 as their functional receptors.
Nature, 612, 2022
7VW2
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BU of 7vw2 by Molmil
Structure of a dimeric periplasmic protein bound with cupric ions
分子名称: COPPER (II) ION, DUF305 domain-containing protein
著者Yang, J, Liu, L.
登録日2021-11-09
公開日2022-01-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.186 Å)
主引用文献Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.
J.Inorg.Biochem., 229, 2022
7VW1
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BU of 7vw1 by Molmil
Structure of a dimeric periplasmic protein bound with cuprous ions
分子名称: COPPER (I) ION, DUF305 domain-containing protein
著者Yang, J, Liu, L.
登録日2021-11-09
公開日2022-01-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.494 Å)
主引用文献Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.
J.Inorg.Biochem., 229, 2022
7VW0
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BU of 7vw0 by Molmil
Structure of a dimeric periplasmic protein
分子名称: DUF305 domain-containing protein
著者Yang, J, Liu, L.
登録日2021-11-09
公開日2022-01-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.447 Å)
主引用文献Structural basis of copper binding by a dimeric periplasmic protein forming a six-helical bundle.
J.Inorg.Biochem., 229, 2022
8HGO
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BU of 8hgo by Molmil
The EGF-bound EGFR/HER2 ectodomain complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ...
著者Zhang, Z, Bai, X.
登録日2022-11-15
公開日2023-02-08
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
8HGP
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BU of 8hgp by Molmil
The EREG-bound EGFR/HER2 ectodomain complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Zhang, Z, Bai, X.
登録日2022-11-15
公開日2023-02-08
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (4.53 Å)
主引用文献Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
8HGS
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BU of 8hgs by Molmil
The EGF-bound EGFR ectodomain homodimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ...
著者Zhang, Z, Bai, X.
登録日2022-11-15
公開日2023-02-15
最終更新日2023-03-01
実験手法ELECTRON MICROSCOPY (3.81 Å)
主引用文献Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
8HKG
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BU of 8hkg by Molmil
Crystal structure of glycosidic hydrolase family 10 (GH10) xylanase XynA contains an additional proline-rich sequence in the C-terminus
分子名称: xylanase
著者Dong, R.Y, Tu, T.
登録日2022-11-26
公開日2023-02-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Effectiveness of ruminal xylanase with an extra proline-rich C-terminus on lignocellulosic biomass degradation.
Bioresour Technol, 372, 2023

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