8JF3
C-Src in complex with compound 9
Summary for 8JF3
| Entry DOI | 10.2210/pdb8jf3/pdb |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide (2 entities in total) |
| Functional Keywords | transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 65867.54 |
| Authors | Zhang, Z.M.,Huang, H.S. (deposition date: 2023-05-17, release date: 2024-02-14, Last modification date: 2024-03-27) |
| Primary citation | Tang, G.,Wang, W.,Zhu, C.,Huang, H.,Chen, P.,Wang, X.,Xu, M.,Sun, J.,Zhang, C.J.,Xiao, Q.,Gao, L.,Zhang, Z.M.,Yao, S.Q. Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew.Chem.Int.Ed.Engl., 63:e202316394-e202316394, 2024 Cited by PubMed: 38248139DOI: 10.1002/anie.202316394 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.84647631109 Å) |
Structure validation
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