5W9N
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5KF4
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8WKJ
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8WOU
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8X5D
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1SO8
| Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)] | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type II, CHLORIDE ION, SODIUM ION | 著者 | Lustbader, J.W, Cirilli, M, Wu, H. | 登録日 | 2004-03-13 | 公開日 | 2004-05-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science, 304, 2004
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7KBB
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7KBA
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7YLO
| Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria Metabolic network of tryptophan around the indole-3-aldehyde formation | 分子名称: | Dyp-type peroxidase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Cheng, J, Luo, Y, Zhu, J, Tan, R, Wang, N, Lebedev, A.A. | 登録日 | 2022-07-26 | 公開日 | 2023-07-05 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria
Metabolic network of tryptophan around the indole-3-aldehyde formation To Be Published
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7YMJ
| Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | 分子名称: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-28 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YMH
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | 分子名称: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-28 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YM8
| Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | 分子名称: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | 著者 | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | 登録日 | 2022-07-27 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YUF
| apo human SPNS2 | 分子名称: | NbFab H-chain, NbFab L-chain, Sphingosine-1-phosphate transporter SPNS2, ... | 著者 | He, Y, Duan, Y. | 登録日 | 2022-08-17 | 公開日 | 2023-09-06 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUD
| FTY720p-bound human SPNS2 | 分子名称: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, NbFab L-chain, NbFab-H-chain, ... | 著者 | He, Y, Duan, Y. | 登録日 | 2022-08-17 | 公開日 | 2023-09-06 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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2W08
| The structure of serum amyloid P component bound to 0-phospho- threonine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PHOSPHOTHREONINE, ... | 著者 | Kolstoe, S.E, Pepys, M.B, Wood, S.P. | 登録日 | 2008-08-12 | 公開日 | 2009-04-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular Dissection of Alzheimer'S Disease Neuropathology by Depletion of Serum Amyloid P Component. Proc.Natl.Acad.Sci.USA, 106, 2009
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4M5C
| Crystal Structure of an Truncated Transition metal Transporter | 分子名称: | COBALT (II) ION, Cobalamin biosynthesis protein CbiM, HEXANE-1,6-DIOL | 著者 | Yu, Y, Zhou, M.Z, Gu, J.K. | 登録日 | 2013-08-08 | 公開日 | 2014-03-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters Cell Res., 24, 2014
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6A53
| Crystal structure of DddK | 分子名称: | MANGANESE (II) ION, Novel protein with potential Cupin domain | 著者 | Zhang, Y.Z, Li, C.Y. | 登録日 | 2018-06-21 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK. Appl. Environ. Microbiol., 85, 2019
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6A54
| Crystal structure of DddK mutant Y64A | 分子名称: | MANGANESE (II) ION, Novel protein with potential Cupin domain | 著者 | Zhang, Y.Z, Li, C.Y. | 登録日 | 2018-06-21 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK. Appl. Environ. Microbiol., 85, 2019
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6A55
| Crystal structure of DddK mutant Y122A | 分子名称: | 3-(dimethyl-lambda~4~-sulfanyl)propanoic acid, MANGANESE (II) ION, Novel protein with potential Cupin domain | 著者 | Zhang, Y.Z, Li, C.Y. | 登録日 | 2018-06-21 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Function Analysis Indicates that an Active-Site Water Molecule Participates in Dimethylsulfoniopropionate Cleavage by DddK. Appl. Environ. Microbiol., 85, 2019
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8WW2
| GPR3/Gs complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Xiong, Y. | 登録日 | 2023-10-24 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
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8FOW
| Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... | 著者 | Schonbrunn, E, Sun, L. | 登録日 | 2023-01-03 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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8FP5
| CDK2 liganded with ATP and Mg2+ | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclin-dependent kinase 2, ... | 著者 | Schonbrunn, E, Sun, L. | 登録日 | 2023-01-04 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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8FP0
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7WE8
| SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | 著者 | Wang, X, Wang, L. | 登録日 | 2021-12-23 | 公開日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
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7WEC
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