8T5K
 
 | | Crystal structure of STING CTD in complex with BDW-OH | | 分子名称: | Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid | | 著者 | Li, Y, Li, P, Sun, D. | | 登録日 | 2023-06-13 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
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8T5L
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7R2E
 | | Structure of human Senp7 with SUMO2 | | 分子名称: | Sentrin-specific protease 7, Small ubiquitin-related modifier 3, prop-2-en-1-amine | | 著者 | Reverter, D, Li, Y. | | 登録日 | 2022-02-04 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural Basis for the SUMO2 Isoform Specificity of SENP7.
J.Mol.Biol., 434, 2022
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7BT6
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7BTB
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1TMM
 | | Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin | | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-HYDROXYMETHYLPTERIN, ACETATE ION, ... | | 著者 | Blaszczyk, J, Li, Y, Wu, Y, Shi, G, Ji, X, Yan, H. | | 登録日 | 2004-06-10 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.
Biochemistry, 44, 2005
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3E5M
 | | Crystal structure of the HSCARG Y81A mutant | | 分子名称: | NmrA-like family domain-containing protein 1 | | 著者 | Li, Y, Meng, G, Dai, X, Luo, M, Zheng, X. | | 登録日 | 2008-08-14 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | NADPH is an allosteric regulator of HSCARG
J.Mol.Biol., 387, 2009
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3DXF
 | | Crystal structure of the HSCARG R37A mutant | | 分子名称: | NmrA-like family domain-containing protein 1 | | 著者 | Li, Y, Meng, G, Dai, X, Luo, M, Zheng, X. | | 登録日 | 2008-07-24 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | NADPH is an allosteric regulator of HSCARG
J.Mol.Biol., 387, 2009
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4GP4
 | | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133F from Thermus thermophilus | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | 著者 | Li, Y, Chen, Y, Stout, C.D. | | 登録日 | 2012-08-20 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases.
Biochemistry, 52, 2013
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4GP8
 | | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133W+T231F from Thermus thermophilus | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | 著者 | Li, Y, Chen, Y, Stout, C.D. | | 登録日 | 2012-08-20 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases.
Biochemistry, 52, 2013
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2IPA
 | | solution structure of Trx-ArsC complex | | 分子名称: | Protein arsC, Thioredoxin | | 著者 | Jin, C, Hu, Y, Li, Y, Zhang, X. | | 登録日 | 2006-10-12 | | 公開日 | 2007-02-13 | | 最終更新日 | 2021-11-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis.
J.Biol.Chem., 282, 2007
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4GP5
 | | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133W from Thermus thermophilus | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | 著者 | Li, Y, Chen, Y, Stout, C.D. | | 登録日 | 2012-08-20 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases.
Biochemistry, 52, 2013
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4ILD
 | | Crystal structure of truncated Bovine viral diarrhea virus 1 E2 envelope protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein E2, ... | | 著者 | Modis, Y, Li, Y, Wang, J. | | 登録日 | 2012-12-30 | | 公開日 | 2013-04-10 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Crystal structure of glycoprotein E2 from bovine viral diarrhea virus.
Proc.Natl.Acad.Sci.USA, 110, 2013
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1NBY
 | | Crystal Structure of HyHEL-63 complexed with HEL mutant K96A | | 分子名称: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | | 著者 | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | | 登録日 | 2002-12-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
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1NBZ
 | | Crystal Structure of HyHEL-63 complexed with HEL mutant K97A | | 分子名称: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | | 著者 | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | | 登録日 | 2002-12-04 | | 公開日 | 2003-04-01 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
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4NQJ
 | | Structure of coiled-coil domain | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, E3 ubiquitin-protein ligase TRIM69 | | 著者 | Yang, M, Li, Y. | | 登録日 | 2013-11-25 | | 公開日 | 2014-05-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.152 Å) | | 主引用文献 | Structural insights into the TRIM family of ubiquitin E3 ligases.
Cell Res., 24, 2014
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6P05
 | | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with compound 27 | | 分子名称: | Bromodomain-containing protein 4, GLYCEROL, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)-1H-indol-4-yl}ethanesulfonamide | | 著者 | Ratia, K.M, Xiong, R, Li, Y, Zhao, J, Gutgesell, L.M, Shen, Z, Dye, K, Dubrovyskyii, O, Zhao, H, Huang, F, Tonetti, D.A, Thatcher, G.R. | | 登録日 | 2019-05-16 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
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5YYF
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6QPQ
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6DWO
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7JKY
 | | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-126 | | 分子名称: | Bromodomain-containing protein 4, N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide, SODIUM ION | | 著者 | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | | 登録日 | 2020-07-29 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
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7JKW
 | | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with ZN1-99 | | 分子名称: | Bromodomain-containing protein 4, N-(6-{5-[(azetidin-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridin-3-yl}-1-[1,1-di(pyridin-2-yl)ethyl]-1H-indol-4-yl)ethanesulfonamide | | 著者 | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | | 登録日 | 2020-07-29 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
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7JKZ
 | | Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126 | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... | | 著者 | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | | 登録日 | 2020-07-29 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63, 2020
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3S5L
 | | Crystal structure of CD4 mutant bound to HLA-DR1 | | 分子名称: | GLYCEROL, HA peptide, HLA class II histocompatibility antigen DR beta chain, ... | | 著者 | Li, Y. | | 登録日 | 2011-05-23 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3S4S
 | | Crystal structure of CD4 mutant bound to HLA-DR1 | | 分子名称: | GLYCEROL, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Li, Y. | | 登録日 | 2011-05-20 | | 公開日 | 2011-09-21 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
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